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• W2736898889 abstract "Abstract Communication between neuronal and glial cells is very important for mainlining brain function across a lifetime. Astroglia can receive and integrate signals from neurons and respond by modulating neuronal activity via release of gliotransmitters. Astrocytes therefore are strategically positioned to mediate the positive influence of enhanced mental and physical activity on the brain function. Still, age- and environment-related changes in astroglial signaling and their impact on brain function remain largely unexplored. Recently we showed the importance of noradrenaline-mediated signaling in the neocortical astrocytes. Noradrenaline did not evoke direct events in neurons but caused significant elevation in the cytosolic Ca2+ in astrocytes that in turn promoted vesicular release of gliotransmitters leading to enhancement of the long-term synaptic plasticity. We found out that adrenergic signaling in the neocortical astrocytes undergoes a considerable age-related decline, but enriched environment can ameliorate this and enhance the adrenergic receptor-triggered release of gliotransmitters. Combined, our data suggest that adrenergic component of astrocyte-neuron communication is important for maintaining the balance between excitatory and inhibitory transmission in the neocortex. This interaction can significantly decline with aging and thus contribute to the age- and pathology-related cognitive impairment." @default.
• W2736898889 created "2017-07-31" @default.
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• W2736898889 date "2017-01-01" @default.
• W2736898889 modified "2023-09-28" @default.
• W2736898889 title "Role for Astroglial α 1 -Adrenergic receptors in Glia-Neuron Communications and Aging-Related Metaplasticity in the Neocortex" @default.
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• W2736898889 doi "https://doi.org/10.1016/b978-0-12-805088-0.00004-9" @default.
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