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• W2736956819 endingPage "825" @default.
• W2736956819 startingPage "820" @default.
• W2736956819 abstract "Multidrug resistance (MDR) cancer toward cancer chemotherapy is one of the obstacles in cancer therapy. Therefore, it is of interested to use formoxanthone C (1,3,5,6-tetraoxygenated xanthone; XanX), a natural compound, which showed cytotoxicity against MDR human A549 lung cancer (A549RT-eto). The treatment with XanX induced not only apoptosis- in A549RT-eto cells, but also autophagy-cell death. Inhibition of apoptosis did not block XanX-induced autophagy in A549RT-eto cells. Furthermore, suppression of autophagy by beclin-1 small interfering RNAs (siRNAs) did not interrupt XanX-induced apoptosis, indicating that XanX can separately induce apoptosis and autophagy. Of interest, XanX treatment reduced levels of histone deacetylase 4 (HDAC4) protein overexpressed in A549RT-etocells. The co-treatment with XanX and HDAC4 siRNA accelerated both autophagy and apoptosis more than that by XanX treatment alone, suggesting survival of HDAC4 in A549RT-eto cells. XanX reverses etoposide resistance in A549RT-eto cells by induction of both autophagy and apoptosis, and confers cytotoxicity through down-regulation of HDAC4." @default.
• W2736956819 created "2017-07-31" @default.
• W2736956819 creator A5003568570 @default.
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• W2736956819 date "2018-02-01" @default.
• W2736956819 modified "2023-09-27" @default.
• W2736956819 title "Formoxanthone C, isolated from Cratoxylum formosum ssp. pruniflorum, reverses anticancer drug resistance by inducing both apoptosis and autophagy in human A549 lung cancer cells" @default.
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• W2736956819 doi "https://doi.org/10.1016/j.bmcl.2017.07.066" @default.
• W2736956819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29402743" @default.
• W2736956819 hasPublicationYear "2018" @default.
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