Matches in SemOpenAlex for { <https://semopenalex.org/work/W2736963908> ?p ?o ?g. }
- W2736963908 endingPage "624" @default.
- W2736963908 startingPage "617" @default.
- W2736963908 abstract "Asparaginase is commonly de-emphasized/omitted in adult acute lymphoblastic leukemia regimens due to poor tolerability, including hepatotoxicity (HTX). Adult patients (n = 100) given induction therapy containing pegylated asparaginase (PEG) from January 2008 to February 2016 were evaluated for HTX. Sixteen patients met criteria for HTX (direct bilirubin >3 g/dL). A multivariable model identified body surface area >2m2 (OR 7.40; 95% CI: 1.73–31.61, p = .007), albumin <3 mg/dL (OR 4.62; 95% CI: 1.09–19.68, p = .038), and platelet count <50 K/mm3 (OR 9.36; 95% CI: 2.13–41.17, p = .003) as risk factors for HTX. More patients with HTX missed ≥1 dose of intended chemotherapy (75% vs. 8%, p < .001). In patients with HTX, complete response and 30-day mortality rates were 40% and 9% versus 73% and 1% in patients without HTX (p = .02 and p < .001). A risk scoring tool was created to predict risk of toxicity, which should be validated through a prospective evaluation." @default.
- W2736963908 created "2017-07-31" @default.
- W2736963908 creator A5003175861 @default.
- W2736963908 creator A5026222436 @default.
- W2736963908 creator A5050975340 @default.
- W2736963908 creator A5052399252 @default.
- W2736963908 creator A5078830268 @default.
- W2736963908 creator A5085532403 @default.
- W2736963908 creator A5086137912 @default.
- W2736963908 date "2017-07-18" @default.
- W2736963908 modified "2023-10-17" @default.
- W2736963908 title "PEGging down risk factors for peg-asparaginase hepatotoxicity in patients with acute lymphoblastic leukemia" @default.
- W2736963908 cites W1595924202 @default.
- W2736963908 cites W1968818148 @default.
- W2736963908 cites W1971341070 @default.
- W2736963908 cites W1999820147 @default.
- W2736963908 cites W2010729137 @default.
- W2736963908 cites W2023882066 @default.
- W2736963908 cites W2026831840 @default.
- W2736963908 cites W2051956423 @default.
- W2736963908 cites W2056667876 @default.
- W2736963908 cites W2068335084 @default.
- W2736963908 cites W2085533078 @default.
- W2736963908 cites W2089471154 @default.
- W2736963908 cites W2106275447 @default.
- W2736963908 cites W2127153931 @default.
- W2736963908 cites W2130838245 @default.
- W2736963908 cites W2131521161 @default.
- W2736963908 cites W2136675187 @default.
- W2736963908 cites W2156840245 @default.
- W2736963908 cites W2157873820 @default.
- W2736963908 cites W2163219205 @default.
- W2736963908 cites W2283305233 @default.
- W2736963908 cites W2305866219 @default.
- W2736963908 cites W2396731999 @default.
- W2736963908 cites W2485785171 @default.
- W2736963908 cites W2506221940 @default.
- W2736963908 cites W2557403188 @default.
- W2736963908 cites W2598325066 @default.
- W2736963908 cites W2603315774 @default.
- W2736963908 cites W2978763137 @default.
- W2736963908 cites W2980143174 @default.
- W2736963908 cites W43170429 @default.
- W2736963908 doi "https://doi.org/10.1080/10428194.2017.1349902" @default.
- W2736963908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28718698" @default.
- W2736963908 hasPublicationYear "2017" @default.
- W2736963908 type Work @default.
- W2736963908 sameAs 2736963908 @default.
- W2736963908 citedByCount "17" @default.
- W2736963908 countsByYear W27369639082017 @default.
- W2736963908 countsByYear W27369639082018 @default.
- W2736963908 countsByYear W27369639082019 @default.
- W2736963908 countsByYear W27369639082020 @default.
- W2736963908 countsByYear W27369639082021 @default.
- W2736963908 countsByYear W27369639082022 @default.
- W2736963908 countsByYear W27369639082023 @default.
- W2736963908 crossrefType "journal-article" @default.
- W2736963908 hasAuthorship W2736963908A5003175861 @default.
- W2736963908 hasAuthorship W2736963908A5026222436 @default.
- W2736963908 hasAuthorship W2736963908A5050975340 @default.
- W2736963908 hasAuthorship W2736963908A5052399252 @default.
- W2736963908 hasAuthorship W2736963908A5078830268 @default.
- W2736963908 hasAuthorship W2736963908A5085532403 @default.
- W2736963908 hasAuthorship W2736963908A5086137912 @default.
- W2736963908 hasConcept C126322002 @default.
- W2736963908 hasConcept C197934379 @default.
- W2736963908 hasConcept C2777501473 @default.
- W2736963908 hasConcept C2778375690 @default.
- W2736963908 hasConcept C2778461978 @default.
- W2736963908 hasConcept C2778904437 @default.
- W2736963908 hasConcept C2909962599 @default.
- W2736963908 hasConcept C71924100 @default.
- W2736963908 hasConcept C90924648 @default.
- W2736963908 hasConceptScore W2736963908C126322002 @default.
- W2736963908 hasConceptScore W2736963908C197934379 @default.
- W2736963908 hasConceptScore W2736963908C2777501473 @default.
- W2736963908 hasConceptScore W2736963908C2778375690 @default.
- W2736963908 hasConceptScore W2736963908C2778461978 @default.
- W2736963908 hasConceptScore W2736963908C2778904437 @default.
- W2736963908 hasConceptScore W2736963908C2909962599 @default.
- W2736963908 hasConceptScore W2736963908C71924100 @default.
- W2736963908 hasConceptScore W2736963908C90924648 @default.
- W2736963908 hasIssue "3" @default.
- W2736963908 hasLocation W27369639081 @default.
- W2736963908 hasLocation W27369639082 @default.
- W2736963908 hasOpenAccess W2736963908 @default.
- W2736963908 hasPrimaryLocation W27369639081 @default.
- W2736963908 hasRelatedWork W2072207948 @default.
- W2736963908 hasRelatedWork W2091767748 @default.
- W2736963908 hasRelatedWork W2092641201 @default.
- W2736963908 hasRelatedWork W2407161884 @default.
- W2736963908 hasRelatedWork W2410889947 @default.
- W2736963908 hasRelatedWork W2413068382 @default.
- W2736963908 hasRelatedWork W2572178017 @default.
- W2736963908 hasRelatedWork W3090233658 @default.
- W2736963908 hasRelatedWork W3130973218 @default.
- W2736963908 hasRelatedWork W4322706357 @default.
- W2736963908 hasVolume "59" @default.