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- W2736990536 abstract "Abstract Multifunctional nanoparticles have high potential as targeting delivery vehicles for cancer chemotherapy. In this study, silver‐decorated gold nanorods (AuNRAg) have been successfully used to deliver specific, targeted chemotherapy against breast cancer (MCF7) and prostate carcinoma (PC3) cell lines. Doxorubicin, a commonly used chemotherapy, and anti‐Epithelial cell adhesion molecule (anti‐EpCAM) antibodies were covalently bonded to thiolated polyethylene glycol‐coated AuNRAg, and the resultant system was used to deliver the drugs to cancer cells in vitro. Furthermore, these nanoparticles have a unique spectral signature by surface enhanced Raman spectroscopy (SERS), which enables reliable detection and monitoring of the distribution of these chemotherapy constructs inside cells. The development of interest in a plasmonic nano drugs system with unique spectroscopic signatures could result in a clinical approach to the precise targeting and visualization of cells and solid tumors while delivering molecules for the enhanced treatment of cancerous tumors." @default.
- W2736990536 created "2017-07-31" @default.
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- W2736990536 date "2017-07-21" @default.
- W2736990536 modified "2023-10-03" @default.
- W2736990536 title "Targeting nano drug delivery to cancer cells using tunable, multi-layer, silver-decorated gold nanorods" @default.
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- W2736990536 doi "https://doi.org/10.1002/jat.3495" @default.
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