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• W2737014550 endingPage "1252" @default.
• W2737014550 startingPage "1252" @default.
• W2737014550 abstract "Type 2 diabetes remains one of the leading causes of death worldwide. Persistent hyperglycemia within a diabetic state is implicated in the generation of oxidative stress and aggravated inflammation that is responsible for accelerated modification of pancreatic beta cell structure. Here we investigated whether a lanosteryl triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA-3), isolated from Protorhus longifolia can improve glucose tolerance and pancreatic beta cell ultrastructure by reducing oxidative stress and inflammation in high fat diet and streptozotocin-induced type 2 diabetes in rats. In addition to impaired glucose tolerance, the untreated diabetic rats showed increased fasting plasma glucose and C-peptide levels. These untreated diabetic rats further demonstrated raised cholesterol, interleukin-6 (IL-6), and lipid peroxidation levels as well as a destroyed beta cell ultrastructure. Treatment with RA-3 was as effective as metformin in improving glucose tolerance and antioxidant effect in the diabetic rats. Interestingly, RA-3 displayed a slightly more enhanced effect than metformin in reducing elevated IL-6 levels and in improving beta cell ultrastructure. Although the involved molecular mechanisms remain to be established, RA-3 demonstrates a strong potential to improve pancreatic beta cell ultrastructure by attenuating impaired glucose tolerance, reducing oxidative stress and inflammation." @default.
• W2737014550 created "2017-07-31" @default.
• W2737014550 creator A5001793973 @default.
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• W2737014550 date "2017-07-26" @default.
• W2737014550 modified "2023-09-25" @default.
• W2737014550 title "A Lanosteryl Triterpene from Protorhus longifolia Improves Glucose Tolerance and Pancreatic Beta Cell Ultrastructure in Type 2 Diabetic Rats" @default.
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• W2737014550 doi "https://doi.org/10.3390/molecules22081252" @default.
• W2737014550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6152316" @default.
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• W2737014550 hasPublicationYear "2017" @default.
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