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- W2737052624 abstract "How cell-type-specific physiological properties shape neuronal functions in a circuit remains poorly understood. We addressed this issue in the Drosophila mushroom body (MB), a higher olfactory circuit, where neurons belonging to distinct glomeruli in the antennal lobe feed excitation to three types of intrinsic neurons, α/β, α'/β', and γ Kenyon cells (KCs). Two-photon optogenetics and intracellular recording revealed that whereas glomerular inputs add similarly in all KCs, spikes were generated most readily in α'/β' KCs. This cell type was also the most competent in recruiting GABAergic inhibition fed back by anterior paired lateral neuron, which responded to odors either locally within a lobe or globally across all lobes depending on the strength of stimuli. Notably, as predicted from these physiological properties, α'/β' KCs had the highest odor detection speed, sensitivity, and discriminability. This enhanced discrimination required proper GABAergic inhibition. These results link cell-type-specific mechanisms and functions in the MB circuit." @default.
- W2737052624 created "2017-07-31" @default.
- W2737052624 creator A5032917195 @default.
- W2737052624 creator A5081551728 @default.
- W2737052624 creator A5088701793 @default.
- W2737052624 date "2017-07-01" @default.
- W2737052624 modified "2023-10-12" @default.
- W2737052624 title "Origins of Cell-Type-Specific Olfactory Processing in the Drosophila Mushroom Body Circuit" @default.
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- W2737052624 doi "https://doi.org/10.1016/j.neuron.2017.06.039" @default.
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