Matches in SemOpenAlex for { <https://semopenalex.org/work/W2737133094> ?p ?o ?g. }
- W2737133094 endingPage "1168" @default.
- W2737133094 startingPage "1157" @default.
- W2737133094 abstract "Matrix metalloproteinase-13 (MMP-13) plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). The subtle differences between the S1' loop of MMP-13 and that of other MMPs offer a structural base for the design of selective MMP-13 inhibitors to mitigate the unperceived risk associated with inhibiting other MMP isoforms. In this review, we summarize zinc-binding and non-zinc-binding selective MMP-13 inhibitors. The zinc-binding MMP-13 inhibitors contain a small set of zinc-binding groups (ZBGs), including hydroxamic acid, pyrimidinetrione, reversed hydroxamic acid and hydantoin, carboxylic acid, 1,2,4,-triazole, and 1,2,4,-triazolone. The non-zinc-binding MMP-13 inhibitors have different structural scaffolds, including diphenyl ethers, biaryls (aryltetrazoliums, arylfurans, pyrazole-indoles), pyrimidines, and aryl/cycloalkyl-fused pyrimidines. This review provides a systematic overview of recent developments in MMP-13 inhibitors for the treatment of OA, with emphasis on their enzyme inhibitory potency, selectivity, and biological activities, and highlights the various binding modes of typical inhibitors with MMP-13." @default.
- W2737133094 created "2017-07-31" @default.
- W2737133094 creator A5040313154 @default.
- W2737133094 creator A5081093022 @default.
- W2737133094 creator A5087231952 @default.
- W2737133094 date "2017-07-19" @default.
- W2737133094 modified "2023-10-02" @default.
- W2737133094 title "Recent Research Advances in Selective Matrix Metalloproteinase-13 Inhibitors as Anti-Osteoarthritis Agents" @default.
- W2737133094 cites W1488574137 @default.
- W2737133094 cites W1818505718 @default.
- W2737133094 cites W1886003831 @default.
- W2737133094 cites W1895946034 @default.
- W2737133094 cites W1966092033 @default.
- W2737133094 cites W1974379524 @default.
- W2737133094 cites W1980942868 @default.
- W2737133094 cites W1982365221 @default.
- W2737133094 cites W1984369802 @default.
- W2737133094 cites W1985456249 @default.
- W2737133094 cites W1986409534 @default.
- W2737133094 cites W1990870094 @default.
- W2737133094 cites W1994512088 @default.
- W2737133094 cites W1996025565 @default.
- W2737133094 cites W1998954104 @default.
- W2737133094 cites W2003500892 @default.
- W2737133094 cites W2004563776 @default.
- W2737133094 cites W2005112244 @default.
- W2737133094 cites W2010242452 @default.
- W2737133094 cites W2010404343 @default.
- W2737133094 cites W2014106390 @default.
- W2737133094 cites W2026915010 @default.
- W2737133094 cites W2035327621 @default.
- W2737133094 cites W2036293026 @default.
- W2737133094 cites W2040523084 @default.
- W2737133094 cites W2040865766 @default.
- W2737133094 cites W2043290769 @default.
- W2737133094 cites W2043857373 @default.
- W2737133094 cites W2046016679 @default.
- W2737133094 cites W2053563346 @default.
- W2737133094 cites W2056715489 @default.
- W2737133094 cites W2058669380 @default.
- W2737133094 cites W2064969450 @default.
- W2737133094 cites W2065173081 @default.
- W2737133094 cites W2070036679 @default.
- W2737133094 cites W2072074880 @default.
- W2737133094 cites W2074842476 @default.
- W2737133094 cites W2076844194 @default.
- W2737133094 cites W2077641860 @default.
- W2737133094 cites W2077859905 @default.
- W2737133094 cites W2082553783 @default.
- W2737133094 cites W2091078620 @default.
- W2737133094 cites W2093353711 @default.
- W2737133094 cites W2099520895 @default.
- W2737133094 cites W2100720198 @default.
- W2737133094 cites W2106677000 @default.
- W2737133094 cites W2108028848 @default.
- W2737133094 cites W2114529565 @default.
- W2737133094 cites W2114798107 @default.
- W2737133094 cites W2124456960 @default.
- W2737133094 cites W2128093567 @default.
- W2737133094 cites W2135136179 @default.
- W2737133094 cites W2135260466 @default.
- W2737133094 cites W2136244824 @default.
- W2737133094 cites W2138960046 @default.
- W2737133094 cites W2150260451 @default.
- W2737133094 cites W2150320607 @default.
- W2737133094 cites W2152573773 @default.
- W2737133094 cites W2154401382 @default.
- W2737133094 cites W2154867920 @default.
- W2737133094 cites W2169098023 @default.
- W2737133094 cites W2171294501 @default.
- W2737133094 cites W2217918056 @default.
- W2737133094 cites W2306757767 @default.
- W2737133094 cites W2310485690 @default.
- W2737133094 cites W2321162589 @default.
- W2737133094 cites W2333515909 @default.
- W2737133094 cites W2335685118 @default.
- W2737133094 cites W2473345834 @default.
- W2737133094 cites W2521041201 @default.
- W2737133094 cites W2561182794 @default.
- W2737133094 cites W2952166462 @default.
- W2737133094 doi "https://doi.org/10.1002/cmdc.201700349" @default.
- W2737133094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28722301" @default.
- W2737133094 hasPublicationYear "2017" @default.
- W2737133094 type Work @default.
- W2737133094 sameAs 2737133094 @default.
- W2737133094 citedByCount "56" @default.
- W2737133094 countsByYear W27371330942018 @default.
- W2737133094 countsByYear W27371330942019 @default.
- W2737133094 countsByYear W27371330942020 @default.
- W2737133094 countsByYear W27371330942021 @default.
- W2737133094 countsByYear W27371330942022 @default.
- W2737133094 countsByYear W27371330942023 @default.
- W2737133094 crossrefType "journal-article" @default.
- W2737133094 hasAuthorship W2737133094A5040313154 @default.
- W2737133094 hasAuthorship W2737133094A5081093022 @default.
- W2737133094 hasAuthorship W2737133094A5087231952 @default.
- W2737133094 hasConcept C107824862 @default.
- W2737133094 hasConcept C109523444 @default.