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• W2737143554 startingPage "3177" @default.
• W2737143554 abstract "Adoptive transfer of T cells engineered to express a hepatitis B virus-specific (HBV-specific) T cell receptor (TCR) may supplement HBV-specific immune responses in chronic HBV patients and facilitate HBV control. However, the risk of triggering unrestrained proliferation of permanently engineered T cells raises safety concerns that have hampered testing of this approach in patients. The aim of the present study was to generate T cells that transiently express HBV-specific TCRs using mRNA electroporation and to assess their antiviral and pathogenetic activity in vitro and in HBV-infected human liver chimeric mice. We assessed virological and gene-expression changes using quantitative reverse-transcriptase PCR (qRT-PCR), immunofluorescence, and Luminex technology. HBV-specific T cells lysed HBV-producing hepatoma cells in vitro. In vivo, 3 injections of HBV-specific T cells caused progressive viremia reduction within 12 days of treatment in animals reconstituted with haplotype-matched hepatocytes, whereas viremia remained stable in mice receiving irrelevant T cells redirected toward hepatitis C virus-specific TCRs. Notably, increases in alanine aminotransferase levels, apoptotic markers, and human inflammatory cytokines returned to pretreatment levels within 9 days after the last injection. T cell transfer did not trigger inflammation in uninfected mice. These data support the feasibility of using mRNA electroporation to engineer HBV TCR-redirected T cells in patients with chronic HBV infection." @default.
• W2737143554 created "2017-07-31" @default.
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• W2737143554 date "2017-07-24" @default.
• W2737143554 modified "2023-10-17" @default.
• W2737143554 title "Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection" @default.
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• W2737143554 doi "https://doi.org/10.1172/jci93024" @default.
• W2737143554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5531408" @default.
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• W2737143554 hasPublicationYear "2017" @default.
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