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- W2737327956 abstract "This book reviews the interaction of oral contraceptives (OCs) with other drugs paying attention to the mechanism of action of drugs which alter the efficacy of the OCs and to ways in which OCs may alter the pharmacology of other drugs. The criteria provided by Drug Interaction Facts is used to classify the clinical significance of the interactions. Recommendations are also given for the management of OC users who need multidrug treatment. The book opens with a review of the mechanisms of drug pharmacokinetic interactions (reduced absorption or reabsorption enzyme induction enzyme inhibition and plasma carrier protein binding) and pharmacodynamic interactions (synergism through enhanced physiological effect and enhanced adverse effects antagonism through decreased physiological effect and decreased adverse effect and other mechanisms). The criteria for the assessment of clinical significance are then reviewed including severity (major moderate and minor) and documentation (established probable suspected possible and unlikely). With this criteria in place the rest of the text is devoted to a consideration of individual drugs according to the following pharmacotherapeutic classification: beta-adrenergic blockers adsorbents alcohol analgesics anticoagulants anticonvulsants antidepressants antihistamines antimicrobials antiparasitics benzodiazepines corticosteroids hypoglycemic drugs immunosuppressants laxatives methylxanthines smoking and vitamins. Data are presented for each drug according to documentation level severity mechanism of action management and clinical significance and references are given for each drug considered." @default.
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- W2737327956 date "1993-01-01" @default.
- W2737327956 modified "2023-09-23" @default.
- W2737327956 title "Summary of drug interactions with oral contraceptives." @default.
- W2737327956 hasPublicationYear "1993" @default.
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