FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2737366920> ?p ?o ?g. }

• W2737366920 endingPage "e015099" @default.
• W2737366920 startingPage "e015099" @default.
• W2737366920 abstract "Atrial fibrillation (AF) is common and causes impaired quality of life, an increased risk of stroke and death as well as frequent hospital admissions. The majority of patients with AF require control of heart rate. In this article , we summarise the limited evidence from clinical trials that guides prescription, and present the rationale and protocol for a new randomised trial. As rate control has not yet been shown to reduce mortality, there is a clear need to compare the impact of therapy on quality of life, cardiac function and exercise capacity. Such a trial should concentrate on the long-term effects of treatment in the largest proportion of patients with AF, those with symptomatic permanent AF, with the aim of improving patient well-being.The RAte control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial will enrol 160 participants with a prospective, randomised, open-label, blinded end point design comparing initial rate control with digoxin or bisoprolol. This will be the first head-to-head randomised trial of digoxin and beta-blockers in AF.Recruited patients will be aged ≥60 years with permanent AF and symptoms of breathlessness (equivalent to New York Heart Association class II or above), with few exclusion criteria to maximise generalisability to routine clinical practice.The primary outcome is patient-reported quality of life, with secondary outcomes including echocardiographic ventricular function, exercise capacity and biomarkers of cellular and clinical response. Follow-up will occur at 6 and 12 months, with feasibility components to inform the design of a future trial powered to detect a difference in hospital admission. The RATE-AF trial will underpin an integrated approach to management including biomarkers, functions and symptoms that will guide future research into optimal, personalised rate control in patients with AF.East Midlands-Derby Research Ethics Committee (16/EM/0178); peer-reviewed publications.Clinicaltrials.gov: NCT02391337; ISRCTN: 95259705. Pre-results." @default.
• W2737366920 created "2017-07-31" @default.
• W2737366920 creator A5001334787 @default.
• W2737366920 creator A5009420648 @default.
• W2737366920 creator A5011475393 @default.
• W2737366920 creator A5017541052 @default.
• W2737366920 creator A5038300932 @default.
• W2737366920 creator A5038405190 @default.
• W2737366920 creator A5047325459 @default.
• W2737366920 creator A5048870331 @default.
• W2737366920 creator A5053645965 @default.
• W2737366920 creator A5072936611 @default.
• W2737366920 creator A5091390414 @default.
• W2737366920 date "2017-07-01" @default.
• W2737366920 modified "2023-10-16" @default.
• W2737366920 title "A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial" @default.
• W2737366920 cites W1207268963 @default.
• W2737366920 cites W1519386588 @default.
• W2737366920 cites W1531214291 @default.
• W2737366920 cites W1717660429 @default.
• W2737366920 cites W183588017 @default.
• W2737366920 cites W1880722242 @default.
• W2737366920 cites W1931064430 @default.
• W2737366920 cites W1964284164 @default.
• W2737366920 cites W1965582006 @default.
• W2737366920 cites W1966942254 @default.
• W2737366920 cites W1969046726 @default.
• W2737366920 cites W1973416160 @default.
• W2737366920 cites W1973633212 @default.
• W2737366920 cites W1975629081 @default.
• W2737366920 cites W1985274076 @default.
• W2737366920 cites W1989801282 @default.
• W2737366920 cites W1990166011 @default.
• W2737366920 cites W1994231358 @default.
• W2737366920 cites W2016423605 @default.
• W2737366920 cites W2031535915 @default.
• W2737366920 cites W2031812050 @default.
• W2737366920 cites W2034762819 @default.
• W2737366920 cites W2035056500 @default.
• W2737366920 cites W2035457614 @default.
• W2737366920 cites W2037585337 @default.
• W2737366920 cites W2038050492 @default.
• W2737366920 cites W2041600410 @default.
• W2737366920 cites W2045872832 @default.
• W2737366920 cites W2053260355 @default.
• W2737366920 cites W2056166846 @default.
• W2737366920 cites W2057467945 @default.
• W2737366920 cites W2059183710 @default.
• W2737366920 cites W2065555011 @default.
• W2737366920 cites W2067396949 @default.
• W2737366920 cites W2068898078 @default.
• W2737366920 cites W2071185134 @default.
• W2737366920 cites W2085806712 @default.
• W2737366920 cites W2089165963 @default.
• W2737366920 cites W2090674352 @default.
• W2737366920 cites W2100922457 @default.
• W2737366920 cites W2102014314 @default.
• W2737366920 cites W2102129403 @default.
• W2737366920 cites W2102658369 @default.
• W2737366920 cites W2110253 @default.
• W2737366920 cites W2111147248 @default.
• W2737366920 cites W2111786081 @default.
• W2737366920 cites W2116736373 @default.
• W2737366920 cites W2117915052 @default.
• W2737366920 cites W2121394112 @default.
• W2737366920 cites W2122259487 @default.
• W2737366920 cites W2124805101 @default.
• W2737366920 cites W2128413398 @default.
• W2737366920 cites W2129290969 @default.
• W2737366920 cites W2130595973 @default.
• W2737366920 cites W2131260805 @default.
• W2737366920 cites W2133435868 @default.
• W2737366920 cites W2137768025 @default.
• W2737366920 cites W2138396513 @default.
• W2737366920 cites W2138806529 @default.
• W2737366920 cites W2147018083 @default.
• W2737366920 cites W2148910374 @default.
• W2737366920 cites W2152235423 @default.
• W2737366920 cites W2153858333 @default.
• W2737366920 cites W2154650976 @default.
• W2737366920 cites W2158493087 @default.
• W2737366920 cites W2159975225 @default.
• W2737366920 cites W2159999579 @default.
• W2737366920 cites W2160601239 @default.
• W2737366920 cites W2162131419 @default.
• W2737366920 cites W2162330026 @default.
• W2737366920 cites W2171811563 @default.
• W2737366920 cites W2219147369 @default.
• W2737366920 cites W2324370521 @default.
• W2737366920 cites W2326136111 @default.
• W2737366920 cites W2340145920 @default.
• W2737366920 cites W2475261460 @default.
• W2737366920 cites W2509394874 @default.
• W2737366920 cites W2509795914 @default.
• W2737366920 cites W2547816089 @default.
• W2737366920 cites W2557294840 @default.
• W2737366920 cites W2604590057 @default.
• W2737366920 cites W2608246596 @default.

• next