FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2737373412> ?p ?o ?g. }

• W2737373412 endingPage "5448" @default.
• W2737373412 startingPage "5448" @default.
• W2737373412 abstract "Abstract Background: Nilotinib, a second generation tyrosine kinase inhibitor, was proved to have high efficacy on treatment of Philadelphia chromosome positive CML patients who failed or were intolerant to imatinib. Limited data was available on its efficacy and safety in Asian population. Methods: Chronic phase CML patients who have failure, suboptimal response or intolerance to imatinib according to ELN 2009 guideline were treated with nilotinib 400 mg twice daily on 7 centers in Thailand. Prospective data collection for 24 months was performed. Results: There were 106 cases participated in this study, 2 cases with initial T315I mutation were excluded from the study, total 104 cases were analysed. The median age was 46 (16-79) years with a slight male predominance over female at the ratio of 1.4:1 respectively. Twenty five percent received imatinib less than 12 months whilst 20% received imatinib longer than 60 months. The median duration of the prior imatinib treatment was 18 months (2-142 months). Best response to imatinib treatment were major molecular response (MMR) 5.8%, complete cytogenetic response (CCyR) 26%, major cytogenetic response (MCyR) 12.5%, complete hematologic response (CHR) 47%, and no CHR 8.7%. The reasons for nilotinib switching were imatinib failure 65%, imatinib intolerance 28%, imatinib suboptimal response 7%. Sixty-eight percent were completed 24 months follow up. Of those, 32% early discontinued treatment mostly because of unsatisfactory results or adverse events. Two patients died of infection and CNS bleeding during the study period. Evaluation were made every 3 months based on ELN 2009 criteria . Best response to nilotinib treatment included MMR 57%, CCyR 16%, MCyR 6%, CHR 16%, and no CHR 5%. At 3 months, 91%, 35%, and 14% of the patients CHR,CCyR, and MMR, respectively. Achieving CCyR or MMR at 3 months predicted a chance of achieving MMR (P= 0.00001) Those who did not achieve at least CHR at 3 months never achieved MMR, while 86 % of those who achieved CCyR at 3 months achieved MMR and 100% of those achieving MMR at 3 months had sustained MMR throughout the study period (24 months). Imatinib suboptimal response had significantly better outcome as compared to imatinib failure and imatinib intolerance group (P = 0.017). All of suboptimal response cases achieved CCyR , 86% achieved MMR, no early discontinue treatment in this group. While 75% of failure group achieved CCyR, 62% achieved MMR and 62% of intolerance group achieved CCyR, 38% achieved MMR. The reason for poorer response of intolerance group was high rate of early discontinue due to side effects, 17% vs 5% in the imatinib failure group. Initial BCR-ABL mutation analysis was performed on 90 cases, mutations were found on 16 cases, 2 of them were T315I which were excluded from the study. The cases with mutation significantly had poorer response to treatment than those without mutation (P = 0.001). There was one case with initial G250E mutation, who developed T315I mutation after treatment with nilotinib. At 24 months, 1 case progressed to accelerated phase and 3 cases progressed to blastic transformation. The 2-year progression-free survival and 2-year overall survival was 96% and 98%, respectively. Skin rash, musculoskeletal pain, and infection were the three most common non-hematologic adverse events found in 18%, 13%, and 6% of the patients, respectively; however, most of them were grade 1-2, except for 4 cases with grade 3-4 infections .Grade 3-4 hematologic adverse events included thrombocytopenia (12%), neutropenia (11%), anemia (5%), and leucopenia (4%); and most of them were manageable. Although biochemical abnormalities were commonly found, most of them were mild. Grade 3-4 events found were hypophosphatemia (6%), hyperglycemia (4%), and elevated serum lipase (4%). Only 10 cases (9%) permanently discontinued nilotinib due to its adverse effects. Conclusions: Nilotinib, as a second line treatment for Thai patients with chronic phase CML showed excellent efficacy and tolerability. Indication for nilotinib treatment, initial mutation status and depth of response at 3 months after treatment can predict outcomes of the patients. Author contact: KanchanaChansung M.D. Division of Hematology, Department of Medicine, Faculty of Medicine, Khonkaen University, Khonkaen, Thailand e-mail: kchansung@gmail.com Disclosures No relevant conflicts of interest to declare." @default.
• W2737373412 created "2017-07-31" @default.
• W2737373412 creator A5022024455 @default.
• W2737373412 creator A5037716264 @default.
• W2737373412 creator A5040263004 @default.
• W2737373412 creator A5046486904 @default.
• W2737373412 creator A5050237877 @default.
• W2737373412 creator A5052903150 @default.
• W2737373412 creator A5058943669 @default.
• W2737373412 creator A5065104304 @default.
• W2737373412 creator A5087456828 @default.
• W2737373412 creator A5087518582 @default.
• W2737373412 creator A5089566522 @default.
• W2737373412 creator A5089927021 @default.
• W2737373412 date "2016-12-02" @default.
• W2737373412 modified "2023-10-16" @default.
• W2737373412 title "Nilotinib As Second-Line Therapy in Patients with Chronic Myeloid Leukemia in Chronic Phase: Thailand Experience" @default.
• W2737373412 doi "https://doi.org/10.1182/blood.v128.22.5448.5448" @default.
• W2737373412 hasPublicationYear "2016" @default.
• W2737373412 type Work @default.
• W2737373412 sameAs 2737373412 @default.
• W2737373412 citedByCount "1" @default.
• W2737373412 countsByYear W27373734122020 @default.
• W2737373412 crossrefType "journal-article" @default.
• W2737373412 hasAuthorship W2737373412A5022024455 @default.
• W2737373412 hasAuthorship W2737373412A5037716264 @default.
• W2737373412 hasAuthorship W2737373412A5040263004 @default.
• W2737373412 hasAuthorship W2737373412A5046486904 @default.
• W2737373412 hasAuthorship W2737373412A5050237877 @default.
• W2737373412 hasAuthorship W2737373412A5052903150 @default.
• W2737373412 hasAuthorship W2737373412A5058943669 @default.
• W2737373412 hasAuthorship W2737373412A5065104304 @default.
• W2737373412 hasAuthorship W2737373412A5087456828 @default.
• W2737373412 hasAuthorship W2737373412A5087518582 @default.
• W2737373412 hasAuthorship W2737373412A5089566522 @default.
• W2737373412 hasAuthorship W2737373412A5089927021 @default.
• W2737373412 hasConcept C121608353 @default.
• W2737373412 hasConcept C126322002 @default.
• W2737373412 hasConcept C141071460 @default.
• W2737373412 hasConcept C197934379 @default.
• W2737373412 hasConcept C2777413986 @default.
• W2737373412 hasConcept C2777583451 @default.
• W2737373412 hasConcept C2778729363 @default.
• W2737373412 hasConcept C2778820342 @default.
• W2737373412 hasConcept C2780007613 @default.
• W2737373412 hasConcept C2780366003 @default.
• W2737373412 hasConcept C2908647359 @default.
• W2737373412 hasConcept C3019892230 @default.
• W2737373412 hasConcept C71924100 @default.
• W2737373412 hasConcept C90924648 @default.
• W2737373412 hasConcept C99454951 @default.
• W2737373412 hasConceptScore W2737373412C121608353 @default.
• W2737373412 hasConceptScore W2737373412C126322002 @default.
• W2737373412 hasConceptScore W2737373412C141071460 @default.
• W2737373412 hasConceptScore W2737373412C197934379 @default.
• W2737373412 hasConceptScore W2737373412C2777413986 @default.
• W2737373412 hasConceptScore W2737373412C2777583451 @default.
• W2737373412 hasConceptScore W2737373412C2778729363 @default.
• W2737373412 hasConceptScore W2737373412C2778820342 @default.
• W2737373412 hasConceptScore W2737373412C2780007613 @default.
• W2737373412 hasConceptScore W2737373412C2780366003 @default.
• W2737373412 hasConceptScore W2737373412C2908647359 @default.
• W2737373412 hasConceptScore W2737373412C3019892230 @default.
• W2737373412 hasConceptScore W2737373412C71924100 @default.
• W2737373412 hasConceptScore W2737373412C90924648 @default.
• W2737373412 hasConceptScore W2737373412C99454951 @default.
• W2737373412 hasIssue "22" @default.
• W2737373412 hasLocation W27373734121 @default.
• W2737373412 hasOpenAccess W2737373412 @default.
• W2737373412 hasPrimaryLocation W27373734121 @default.
• W2737373412 hasRelatedWork W1974135663 @default.
• W2737373412 hasRelatedWork W2051726599 @default.
• W2737373412 hasRelatedWork W2068117867 @default.
• W2737373412 hasRelatedWork W2073935113 @default.
• W2737373412 hasRelatedWork W2120868842 @default.
• W2737373412 hasRelatedWork W2135349074 @default.
• W2737373412 hasRelatedWork W2184746615 @default.
• W2737373412 hasRelatedWork W2488200262 @default.
• W2737373412 hasRelatedWork W4230849756 @default.
• W2737373412 hasRelatedWork W4245675997 @default.
• W2737373412 hasVolume "128" @default.
• W2737373412 isParatext "false" @default.
• W2737373412 isRetracted "false" @default.
• W2737373412 magId "2737373412" @default.
• W2737373412 workType "article" @default.