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- W2737392340 endingPage "168" @default.
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- W2737392340 abstract "The rate of local recurrences, after breast-conserving surgery or mastectomy for hormone receptor-positive (HR+) breast cancer, has dramatically changed in last decades, due to advances in surgical and radiation techniques and a more extensive use of adjuvant systemic treatments. However, the occurrence of local recurrences remains a major predictor for distant metastasis and is responsible for increased cancer-specific death. It has been estimated that 1 in 4 HR+ and HR-ipsilateral breast recurrences leads to widespread metastatic disease, with an annual mortality rate of 10% in the first 5 years. Nevertheless, very few studies have been conducted to evaluate the optimal care of purely HR+ local relapses of breast cancer, after surgical removal. In this review we have highlighted the available knowledge on prognostic assessment and systemic treatment for women experiencing local relapses of HR+ breast cancers, underlying unsolved questions and controversial clinical aspects." @default.
- W2737392340 created "2017-07-31" @default.
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- W2737392340 date "2017-10-01" @default.
- W2737392340 modified "2023-10-14" @default.
- W2737392340 title "Prognostic assessment and systemic treatments of invasive local relapses of hormone receptor-positive breast cancer" @default.
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- W2737392340 doi "https://doi.org/10.1016/j.breast.2017.07.013" @default.
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