Matches in SemOpenAlex for { <https://semopenalex.org/work/W2737499959> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2737499959 abstract "Aim: Thirty percent of epileptic patients are refractory to treatment. We investigated the association between the number of seizures in refractory epileptic patients and potential interactions between their antiepileptic medications (AEDs) and single nucleotide polymorphisms in genes ABCB1, CYP2C9 and EPHX1. Methods: Thirty-three adult patients were included and tested for genetic variations using the Neuropharmagen ® test. Retrospective data on AED therapy and number of seizures during the 12 months before inclusion were extracted from clinical records. Results: Patients displaying potential single nucleotide polymorphisms × AED interactions had a median of 14.5 seizures during the previous 12 months (IQR 5.5–105.0), compared to a median of 7.0 seizures (IQR 4.0–12.0) in patients without these interactions (univariate p = 0.051, adjusted p = 0.034). Conclusion: Refractory patients carrying genetic variations potentially affecting their AED medication experienced a significantly higher number of seizures. Thus, genotyping could help to better control epilepsy in some refractory patients." @default.
- W2737499959 created "2017-07-31" @default.
- W2737499959 creator A5011789114 @default.
- W2737499959 creator A5044431149 @default.
- W2737499959 creator A5052209292 @default.
- W2737499959 creator A5077473599 @default.
- W2737499959 creator A5080577121 @default.
- W2737499959 creator A5084402585 @default.
- W2737499959 date "2017-08-01" @default.
- W2737499959 modified "2023-09-28" @default.
- W2737499959 title "Polymorphisms in ABCB1 and EPHX1 genes influence drug effectiveness in refractory epilepsy: a retrospective study" @default.
- W2737499959 cites W1920696238 @default.
- W2737499959 cites W1977023935 @default.
- W2737499959 cites W1995274127 @default.
- W2737499959 cites W2005700694 @default.
- W2737499959 cites W2016709429 @default.
- W2737499959 cites W2024273461 @default.
- W2737499959 cites W2026084712 @default.
- W2737499959 cites W2034838499 @default.
- W2737499959 cites W2040185039 @default.
- W2737499959 cites W2041057539 @default.
- W2737499959 cites W2156624148 @default.
- W2737499959 cites W2313166539 @default.
- W2737499959 cites W2528596420 @default.
- W2737499959 cites W2531859534 @default.
- W2737499959 cites W2600679849 @default.
- W2737499959 cites W4211013529 @default.
- W2737499959 doi "https://doi.org/10.2217/fnl-2016-0026" @default.
- W2737499959 hasPublicationYear "2017" @default.
- W2737499959 type Work @default.
- W2737499959 sameAs 2737499959 @default.
- W2737499959 citedByCount "0" @default.
- W2737499959 crossrefType "journal-article" @default.
- W2737499959 hasAuthorship W2737499959A5011789114 @default.
- W2737499959 hasAuthorship W2737499959A5044431149 @default.
- W2737499959 hasAuthorship W2737499959A5052209292 @default.
- W2737499959 hasAuthorship W2737499959A5077473599 @default.
- W2737499959 hasAuthorship W2737499959A5080577121 @default.
- W2737499959 hasAuthorship W2737499959A5084402585 @default.
- W2737499959 hasConcept C118552586 @default.
- W2737499959 hasConcept C126322002 @default.
- W2737499959 hasConcept C142424586 @default.
- W2737499959 hasConcept C144301174 @default.
- W2737499959 hasConcept C167135981 @default.
- W2737499959 hasConcept C187212893 @default.
- W2737499959 hasConcept C2777332695 @default.
- W2737499959 hasConcept C2778186239 @default.
- W2737499959 hasConcept C2780035454 @default.
- W2737499959 hasConcept C38180746 @default.
- W2737499959 hasConcept C71924100 @default.
- W2737499959 hasConcept C86803240 @default.
- W2737499959 hasConcept C87355193 @default.
- W2737499959 hasConcept C98274493 @default.
- W2737499959 hasConceptScore W2737499959C118552586 @default.
- W2737499959 hasConceptScore W2737499959C126322002 @default.
- W2737499959 hasConceptScore W2737499959C142424586 @default.
- W2737499959 hasConceptScore W2737499959C144301174 @default.
- W2737499959 hasConceptScore W2737499959C167135981 @default.
- W2737499959 hasConceptScore W2737499959C187212893 @default.
- W2737499959 hasConceptScore W2737499959C2777332695 @default.
- W2737499959 hasConceptScore W2737499959C2778186239 @default.
- W2737499959 hasConceptScore W2737499959C2780035454 @default.
- W2737499959 hasConceptScore W2737499959C38180746 @default.
- W2737499959 hasConceptScore W2737499959C71924100 @default.
- W2737499959 hasConceptScore W2737499959C86803240 @default.
- W2737499959 hasConceptScore W2737499959C87355193 @default.
- W2737499959 hasConceptScore W2737499959C98274493 @default.
- W2737499959 hasLocation W27374999591 @default.
- W2737499959 hasOpenAccess W2737499959 @default.
- W2737499959 hasPrimaryLocation W27374999591 @default.
- W2737499959 hasRelatedWork W1506542347 @default.
- W2737499959 hasRelatedWork W1984882006 @default.
- W2737499959 hasRelatedWork W2020447663 @default.
- W2737499959 hasRelatedWork W2030449842 @default.
- W2737499959 hasRelatedWork W2068208010 @default.
- W2737499959 hasRelatedWork W2081281742 @default.
- W2737499959 hasRelatedWork W2110526135 @default.
- W2737499959 hasRelatedWork W2135116638 @default.
- W2737499959 hasRelatedWork W2143843681 @default.
- W2737499959 hasRelatedWork W2426407894 @default.
- W2737499959 hasRelatedWork W2507701231 @default.
- W2737499959 hasRelatedWork W2525564551 @default.
- W2737499959 hasRelatedWork W253864907 @default.
- W2737499959 hasRelatedWork W2739828464 @default.
- W2737499959 hasRelatedWork W3023450964 @default.
- W2737499959 hasRelatedWork W3042278875 @default.
- W2737499959 hasRelatedWork W3092067959 @default.
- W2737499959 hasRelatedWork W3092075283 @default.
- W2737499959 hasRelatedWork W3168348346 @default.
- W2737499959 hasRelatedWork W2299976703 @default.
- W2737499959 isParatext "false" @default.
- W2737499959 isRetracted "false" @default.
- W2737499959 magId "2737499959" @default.
- W2737499959 workType "article" @default.