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- W2737538985 abstract "Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates are a class of drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common and rare genetic variants that impact lipid responses to fenofibrate in statin-treated patients with T2D, we examined lipid changes in response to fenofibrate therapy using a genomewide association study (GWAS). Associations were followed-up using gene expression studies in mice. Common variants in SMAD3 and IPO11 were marginally associated with lipid changes in black subjects (P < 5 × 10-6 ). Rare variant and gene expression changes were assessed using a false discovery rate approach. AKR7A3 and HSD17B13 were associated with lipid changes in white subjects (q < 0.2). Mice fed fenofibrate displayed reductions in Hsd17b13 gene expression (q < 0.1). Associations of variants in SMAD3, IPO11, and HSD17B13, with gene expression changes in mice indicate that transforming growth factor-beta (TGF-β) and NRF2 signaling pathways may influence fenofibrate effects on dyslipidemia in patients with T2D." @default.
- W2737538985 created "2017-07-31" @default.
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- W2737538985 date "2017-11-03" @default.
- W2737538985 modified "2023-10-18" @default.
- W2737538985 title "Genetic Variants in<i>HSD17B3</i>,<i>SMAD3</i>, and<i>IPO11</i>Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes" @default.
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- W2737538985 doi "https://doi.org/10.1002/cpt.798" @default.
- W2737538985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5828950" @default.
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