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- W2737674920 abstract "Significance General anesthesia is a drug-induced state of altered arousal associated with profound, stereotyped electrophysiological oscillations. Here we report evidence in rats that propofol, an anesthetic drug frequently used in clinical practice, disrupts activity in medial prefrontal cortex and thalamus by inducing highly synchronized oscillations between these structures. These oscillations closely parallel human electroencephalogram oscillations under propofol. Disruption of activity in medial prefrontal cortex by these oscillations implies an impairment of self-awareness and internal consciousness. During recovery of consciousness, these synchronized oscillations dissipate in a “boot-up” sequence most likely driven by ascending arousal centers. These studies advance our understanding of what it means to be unconscious under anesthesia and establish principled neurophysiological markers to monitor and manage this state." @default.
- W2737674920 created "2017-07-31" @default.
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- W2737674920 date "2017-07-25" @default.
- W2737674920 modified "2023-10-14" @default.
- W2737674920 title "Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness" @default.
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- W2737674920 doi "https://doi.org/10.1073/pnas.1700148114" @default.
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