Matches in SemOpenAlex for { <https://semopenalex.org/work/W2737766111> ?p ?o ?g. }
- W2737766111 endingPage "725" @default.
- W2737766111 startingPage "711" @default.
- W2737766111 abstract "Glycosaminoglycans (GAGs) in marine animals are different to those of terrestrial organisms, mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are related to their ability to interact with proteins, which is very much influenced by sulfation position and patterns. Since currently GAGs cannot be chemically synthesized, they are sourced from natural products, with high intra- but also inter-species variability, in terms of chain length, disaccharide composition and sulfation pattern. Consequently, sulfated GAGs are the most interesting molecules in the marine environment and constitute the focus of the present review. In particular, chondroitin sulfate (CS) appears as the most promising compound. CS-E chains [GlcA-GalNAc(4S,6S)] extracted from squid possess antiviral and anti-metastatic activities and seem to impart signalling properties and improve the mechanical performance of cartilage engineering constructs; Squid CS-E and octopus CS-K [GlcA(3S)-GalNAc(4S)], dermatan sulfate (DS) from sea squirts [-iK units, IdoA(3S)-GalNAc(4S)] and sea urchins [-iE units, IdoA-GalNAc(4S,6S)] and hybrids CS/DS from sharks (-B/iB [GlcA/IdoA(2S)-GalNAc(4S)], -D/iD [GlcA/IdoA(2S)-GalNAc(6S)] and –E/iE units [GlcA/IdoA-GalNAc(4S,6S)]) promote neurite outgrowth and could be valuable materials for nerve regeneration. Also displaying antiviral and anti-metastatic properties, a rare CS with fucosylated branches isolated from sea cucumbers is an anticoagulant and anti-inflammatory agent. In this same line, marine heparin extracted from shrimp and sea squirt has proven anti-inflammatory properties, with the added advantage of decreased risk of bleeding because of its low anticoagulant activity." @default.
- W2737766111 created "2017-07-31" @default.
- W2737766111 creator A5019596297 @default.
- W2737766111 creator A5075034238 @default.
- W2737766111 creator A5079730556 @default.
- W2737766111 creator A5081499203 @default.
- W2737766111 creator A5091140842 @default.
- W2737766111 date "2017-11-01" @default.
- W2737766111 modified "2023-10-17" @default.
- W2737766111 title "Glycosaminoglycans from marine sources as therapeutic agents" @default.
- W2737766111 cites W1181717787 @default.
- W2737766111 cites W1442816972 @default.
- W2737766111 cites W1503784274 @default.
- W2737766111 cites W1507206095 @default.
- W2737766111 cites W1514072822 @default.
- W2737766111 cites W1524677126 @default.
- W2737766111 cites W1525100104 @default.
- W2737766111 cites W1588414812 @default.
- W2737766111 cites W1600328375 @default.
- W2737766111 cites W1755323321 @default.
- W2737766111 cites W1771887010 @default.
- W2737766111 cites W1778960512 @default.
- W2737766111 cites W1806451165 @default.
- W2737766111 cites W1906200957 @default.
- W2737766111 cites W1963566022 @default.
- W2737766111 cites W1970445147 @default.
- W2737766111 cites W1972898307 @default.
- W2737766111 cites W1975980965 @default.
- W2737766111 cites W1977428596 @default.
- W2737766111 cites W1978283023 @default.
- W2737766111 cites W1982423863 @default.
- W2737766111 cites W1982634200 @default.
- W2737766111 cites W1983871161 @default.
- W2737766111 cites W1984402172 @default.
- W2737766111 cites W1985735581 @default.
- W2737766111 cites W1986547423 @default.
- W2737766111 cites W1988534292 @default.
- W2737766111 cites W1990306679 @default.
- W2737766111 cites W1990991190 @default.
- W2737766111 cites W1993632935 @default.
- W2737766111 cites W1994426317 @default.
- W2737766111 cites W1994974479 @default.
- W2737766111 cites W1999471762 @default.
- W2737766111 cites W2000460436 @default.
- W2737766111 cites W2001371234 @default.
- W2737766111 cites W2003277888 @default.
- W2737766111 cites W2004105242 @default.
- W2737766111 cites W2004590551 @default.
- W2737766111 cites W2004785268 @default.
- W2737766111 cites W2007041146 @default.
- W2737766111 cites W2007544193 @default.
- W2737766111 cites W2011815227 @default.
- W2737766111 cites W2012027930 @default.
- W2737766111 cites W2012928251 @default.
- W2737766111 cites W2013623858 @default.
- W2737766111 cites W2014449340 @default.
- W2737766111 cites W2014788501 @default.
- W2737766111 cites W2015262545 @default.
- W2737766111 cites W2015268137 @default.
- W2737766111 cites W2016519321 @default.
- W2737766111 cites W2019085666 @default.
- W2737766111 cites W2019216320 @default.
- W2737766111 cites W2024423297 @default.
- W2737766111 cites W2025557523 @default.
- W2737766111 cites W2026318687 @default.
- W2737766111 cites W2026405749 @default.
- W2737766111 cites W2027396609 @default.
- W2737766111 cites W2031354813 @default.
- W2737766111 cites W2031780617 @default.
- W2737766111 cites W2033818437 @default.
- W2737766111 cites W2035809865 @default.
- W2737766111 cites W2036334243 @default.
- W2737766111 cites W2038925467 @default.
- W2737766111 cites W2039223035 @default.
- W2737766111 cites W2039900815 @default.
- W2737766111 cites W2044729848 @default.
- W2737766111 cites W2045308024 @default.
- W2737766111 cites W2045786019 @default.
- W2737766111 cites W2046239638 @default.
- W2737766111 cites W2048257558 @default.
- W2737766111 cites W2050115447 @default.
- W2737766111 cites W2051872201 @default.
- W2737766111 cites W2053003892 @default.
- W2737766111 cites W2054607818 @default.
- W2737766111 cites W2056742992 @default.
- W2737766111 cites W2058051209 @default.
- W2737766111 cites W2058064653 @default.
- W2737766111 cites W2060193456 @default.
- W2737766111 cites W2061815997 @default.
- W2737766111 cites W2061871064 @default.
- W2737766111 cites W2062060788 @default.
- W2737766111 cites W2065445985 @default.
- W2737766111 cites W2065939980 @default.
- W2737766111 cites W2066371891 @default.
- W2737766111 cites W2067335250 @default.
- W2737766111 cites W2067379855 @default.
- W2737766111 cites W2067890105 @default.
- W2737766111 cites W2070120565 @default.