FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2737980520> ?p ?o ?g. }

• W2737980520 endingPage "1710" @default.
• W2737980520 startingPage "1702" @default.
• W2737980520 abstract "The principal initial biological targets of free radicals formed under conditions of oxidative stress are the proteins. The most common products of the interaction are carbon-centered alkyl radicals which react rapidly with oxygen to form peroxyl radicals and hydroperoxides. All these species are reactive, capable of propagating the free radical damage to enzymes, nucleic acids, lipids, and endogenous antioxidants, leading finally to the pathologies associated with oxidative stress. The best chance of preventing this chain of damage is in early repair of the protein radicals by antioxidants. Estimate of the effectiveness of the physiologically significant antioxidants requires knowledge of the antioxidant tissue concentrations and rate constants of their reaction with protein radicals. Previous studies by pulse radiolysis have shown that only ascorbate can repair the Trp and Tyr protein radicals before they form peroxyl radicals under physiological concentrations of oxygen. We have now extended this work to other protein C-centered radicals generated by hydroxyl radicals because these and many other free radicals formed under oxidative stress can produce secondary radicals on virtually any amino acid residue. Pulse radiolysis identified two classes of rate constants for reactions of protein radicals with ascorbate, a faster one in the range (9-60) × 107 M-1 s-1 and a slow one with a range of (0.5-2) × 107 M-1 s-1. These results show that ascorbate can prevent further reactions of protein radicals only in the few human tissues where its concentration exceeds about 2.5 mM." @default.
• W2737980520 created "2017-07-31" @default.
• W2737980520 creator A5012909938 @default.
• W2737980520 creator A5030820947 @default.
• W2737980520 date "2017-08-29" @default.
• W2737980520 modified "2023-10-16" @default.
• W2737980520 title "Physiological Concentrations of Ascorbate Cannot Prevent the Potentially Damaging Reactions of Protein Radicals in Humans" @default.
• W2737980520 cites W1926950498 @default.
• W2737980520 cites W193764218 @default.
• W2737980520 cites W1968081965 @default.
• W2737980520 cites W1969982879 @default.
• W2737980520 cites W1974810526 @default.
• W2737980520 cites W1991952977 @default.
• W2737980520 cites W1995336814 @default.
• W2737980520 cites W2000143363 @default.
• W2737980520 cites W2003670869 @default.
• W2737980520 cites W2015852310 @default.
• W2737980520 cites W2017144791 @default.
• W2737980520 cites W2024300734 @default.
• W2737980520 cites W2024331268 @default.
• W2737980520 cites W203315287 @default.
• W2737980520 cites W2040093709 @default.
• W2737980520 cites W2048676468 @default.
• W2737980520 cites W2052278107 @default.
• W2737980520 cites W2064820284 @default.
• W2737980520 cites W2065876395 @default.
• W2737980520 cites W2068119928 @default.
• W2737980520 cites W2095278996 @default.
• W2737980520 cites W2097139107 @default.
• W2737980520 cites W2099776063 @default.
• W2737980520 cites W2137197828 @default.
• W2737980520 cites W2146459006 @default.
• W2737980520 cites W2156057127 @default.
• W2737980520 cites W2316174071 @default.
• W2737980520 cites W2318905955 @default.
• W2737980520 cites W2329981499 @default.
• W2737980520 cites W2460935569 @default.
• W2737980520 cites W2480806707 @default.
• W2737980520 doi "https://doi.org/10.1021/acs.chemrestox.7b00160" @default.
• W2737980520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28745873" @default.
• W2737980520 hasPublicationYear "2017" @default.
• W2737980520 type Work @default.
• W2737980520 sameAs 2737980520 @default.
• W2737980520 citedByCount "10" @default.
• W2737980520 countsByYear W27379805202017 @default.
• W2737980520 countsByYear W27379805202018 @default.
• W2737980520 countsByYear W27379805202019 @default.
• W2737980520 countsByYear W27379805202021 @default.
• W2737980520 countsByYear W27379805202022 @default.
• W2737980520 countsByYear W27379805202023 @default.
• W2737980520 crossrefType "journal-article" @default.
• W2737980520 hasAuthorship W2737980520A5012909938 @default.
• W2737980520 hasAuthorship W2737980520A5030820947 @default.
• W2737980520 hasConcept C121332964 @default.
• W2737980520 hasConcept C139066938 @default.
• W2737980520 hasConcept C148898269 @default.
• W2737980520 hasConcept C185592680 @default.
• W2737980520 hasConcept C2776151105 @default.
• W2737980520 hasConcept C2778004101 @default.
• W2737980520 hasConcept C2986274086 @default.
• W2737980520 hasConcept C31903555 @default.
• W2737980520 hasConcept C55493867 @default.
• W2737980520 hasConcept C57600042 @default.
• W2737980520 hasConcept C62520636 @default.
• W2737980520 hasConcept C66887884 @default.
• W2737980520 hasConcept C75473681 @default.
• W2737980520 hasConcept C93391505 @default.
• W2737980520 hasConceptScore W2737980520C121332964 @default.
• W2737980520 hasConceptScore W2737980520C139066938 @default.
• W2737980520 hasConceptScore W2737980520C148898269 @default.
• W2737980520 hasConceptScore W2737980520C185592680 @default.
• W2737980520 hasConceptScore W2737980520C2776151105 @default.
• W2737980520 hasConceptScore W2737980520C2778004101 @default.
• W2737980520 hasConceptScore W2737980520C2986274086 @default.
• W2737980520 hasConceptScore W2737980520C31903555 @default.
• W2737980520 hasConceptScore W2737980520C55493867 @default.
• W2737980520 hasConceptScore W2737980520C57600042 @default.
• W2737980520 hasConceptScore W2737980520C62520636 @default.
• W2737980520 hasConceptScore W2737980520C66887884 @default.
• W2737980520 hasConceptScore W2737980520C75473681 @default.
• W2737980520 hasConceptScore W2737980520C93391505 @default.
• W2737980520 hasFunder F4320320591 @default.
• W2737980520 hasFunder F4320321652 @default.
• W2737980520 hasIssue "9" @default.
• W2737980520 hasLocation W27379805201 @default.
• W2737980520 hasLocation W27379805202 @default.
• W2737980520 hasOpenAccess W2737980520 @default.
• W2737980520 hasPrimaryLocation W27379805201 @default.
• W2737980520 hasRelatedWork W1964249238 @default.
• W2737980520 hasRelatedWork W1992381058 @default.
• W2737980520 hasRelatedWork W2002346633 @default.
• W2737980520 hasRelatedWork W2017524426 @default.
• W2737980520 hasRelatedWork W2030341670 @default.
• W2737980520 hasRelatedWork W2039822379 @default.
• W2737980520 hasRelatedWork W2058344142 @default.
• W2737980520 hasRelatedWork W2062163549 @default.
• W2737980520 hasRelatedWork W2066185644 @default.
• W2737980520 hasRelatedWork W2082216829 @default.

• next