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- W2737993948 abstract "Cerebral ischemia/reperfusion (I/R) is a lethal and disabling disease. Studies have suggested that hyperglycemia is a risk factor for cerebral I/R. Baicalin is a natural bioactive flavonoid extracted from Scutellaria baicalensis Georgi with neuroprotective activity. In the present study, we investigated the effects of baicalin on hyperglycemia-exacerbated cerebral I/R injury. Streptozotocin (STZ) injection aggravated the brain damage induced by middle cerebral artery occlusion (MCAO) surgery, while baicalin administration reduced blood glucose, relieved neurological deficit and decreased infarct volume. In vitro, Oxygen-glucose deprivation/ reperfusion (OGD/REP) induced inordinate reactive oxygen species (ROS) production and mitochondrial dynamic impairments were markedly increased under high glucose (HG) condition. Baicalin treatment in PC12 cells inhibited dynamin-related protein 1 (Drp-1) expression, decreased mitochondrial fission, promoted mitofusin-2 (MFN2) generation, increased Drp-1 Ser637 phosphorylation, and elevated mitochondrial membrane potential (Δψm) via the suppression of ROS production. However, AMPKα1 knockdown abolished the protective effects of baicalin. Baicalin also suppressed cell apoptosis and enhanced mitophagy. These results suggested that baicalin protected against hyperglycemia aggravated I/R injury by regulating mitochondrial functions in a manner dependent on AMPK." @default.
- W2737993948 created "2017-07-31" @default.
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- W2737993948 date "2017-11-01" @default.
- W2737993948 modified "2023-10-18" @default.
- W2737993948 title "Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK" @default.
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- W2737993948 cites W1754624260 @default.
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- W2737993948 cites W1975394768 @default.
- W2737993948 cites W1981102645 @default.
- W2737993948 cites W1982049788 @default.
- W2737993948 cites W1987845572 @default.
- W2737993948 cites W1992080421 @default.
- W2737993948 cites W1996234796 @default.
- W2737993948 cites W1999931656 @default.
- W2737993948 cites W2016752484 @default.
- W2737993948 cites W2020722847 @default.
- W2737993948 cites W2025166615 @default.
- W2737993948 cites W2028830825 @default.
- W2737993948 cites W2035477351 @default.
- W2737993948 cites W2042515284 @default.
- W2737993948 cites W2042880990 @default.
- W2737993948 cites W2043850619 @default.
- W2737993948 cites W2047671688 @default.
- W2737993948 cites W2052136666 @default.
- W2737993948 cites W2055297290 @default.
- W2737993948 cites W2056906224 @default.
- W2737993948 cites W2063729545 @default.
- W2737993948 cites W2068312338 @default.
- W2737993948 cites W2073819646 @default.
- W2737993948 cites W2074710857 @default.
- W2737993948 cites W2074937649 @default.
- W2737993948 cites W2081003067 @default.
- W2737993948 cites W2081550541 @default.
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- W2737993948 cites W2085335902 @default.
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- W2737993948 cites W2096299938 @default.
- W2737993948 cites W2103659405 @default.
- W2737993948 cites W2112505121 @default.
- W2737993948 cites W2116562304 @default.
- W2737993948 cites W2128347259 @default.
- W2737993948 cites W2131052402 @default.
- W2737993948 cites W2138393223 @default.
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- W2737993948 cites W2161291398 @default.
- W2737993948 cites W2164469233 @default.
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- W2737993948 cites W2192518464 @default.
- W2737993948 cites W2236270374 @default.
- W2737993948 cites W2291168073 @default.
- W2737993948 cites W2301918656 @default.
- W2737993948 cites W2308741082 @default.
- W2737993948 cites W2316843857 @default.
- W2737993948 cites W2346657736 @default.
- W2737993948 cites W2384095166 @default.
- W2737993948 cites W2401831534 @default.
- W2737993948 cites W2404952942 @default.
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- W2737993948 doi "https://doi.org/10.1016/j.ejphar.2017.07.041" @default.
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