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- W2738022009 abstract "Recent analyses in patients with ALK positive non–small cell lung cancer (NSCLC) treated with crizotinib have demonstrated an association between larger depth of response and improved progression free survival and overall survival. These data suggest that reduction of this residual disease compartment may present an alternative strategy to improve survival and is consistent with the idea that this residual disease compartment is the origin of tumor cells that ultimately drive disease progression. Thus, studies analyzing the characteristics of this reservoir are needed to determine how to target this compartment. We have developed two clinical trials to facilitate the characterization of the residual disease compartment in patients with NSCLC. The first trial will accrue patients with early stage ALK, ROS1 or MET mutated NSCLC. Patients will receive 6 weeks of neoadjuvant treatment with crizotinib followed by surgical resection. The second trial will enroll patients with stage IV EGFR mutated NSCLC. Patients will undergo a pre-treatment biopsy and a repeat biopsy of the same lesion two weeks after starting treatment with an EGFR inhibitor. Tumor specimens from both studies will be evaluated with RNA Seq, multiparameter protein expression analysis and proximity ligation assays to identify early adaptive mechanisms of cell survival in the setting of oncogene-targeted therapy. Similar to post-progression biopsies that allowed identification of mechanisms of acquired resistance, these clinical trials will facilitate identification of early escape mechanisms from targeted therapy." @default.
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- W2738022009 date "2017-08-01" @default.
- W2738022009 modified "2023-09-26" @default.
- W2738022009 title "Targeting Residual Disease in Oncogene-Driven NSCLC" @default.
- W2738022009 doi "https://doi.org/10.1016/j.jtho.2017.06.064" @default.
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