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• W2738119232 abstract "Significance Mitochondrial perturbation-associated dysregulation of one organ has been shown to nonautonomously affect the functions of other organs in both vertebrates and invertebrates. Using Drosophila as a genetic model organism, we characterized mitochondrial synchrony dysregulation across organs and uncovered that mitochondrial perturbation caused by complex I disruption in muscles remotely impairs mitochondrial function and lipid mobilization in the fat body, leading to obesity. We further identified that the TGF-β ligand Actβ, which is autonomously increased by muscular mitochondrial perturbation, mediates muscle-to-fat-body communication and synchronized mitochondrial dysregulation." @default.
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• W2738119232 date "2017-07-24" @default.
• W2738119232 modified "2023-10-17" @default.
• W2738119232 title "Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model" @default.
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• W2738119232 doi "https://doi.org/10.1073/pnas.1708037114" @default.
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