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• W2738181886 abstract "ABSTRACT Preclinical Research The diterpene ent‐dihydrotumanoic acid (DTA) was among the compounds isolated from Gymnosperma glutinosum (Spreng) Less (Asteraceae). There are no reports regarding the pharmacological effects of DTA. Cytotoxicity against cancer cells (1–250 µM), and the antibacterial (50–1400 µM) activity of DTA were evaluated using the MTT assay, and the minimum inhibitory concentration test, respectively. The antidiarrheal (1–100 mg/kg p.o.) and anti‐inflammatory (2 mg/ear) effects of DTA were evaluated using castor oil and 12 ‐O‐ tetradecanoylphorbol ‐ 13 ‐ acetate, respectively. The antinociceptive and sedative effects of DTA (1–100 mg/kg p.o.) were evaluated using two models of chemically‐induced nociception, and the pentobarbital‐induced sleeping time test, respectively. The antinociceptive mechanism of DTA was evaluated using the acetic acid writhing test with inhibitors related to pain processing pathways. The effects of DTA (10–100 mg/kg p.o.) on locomotor activity were evaluated using the rotarod test. DTA lacked cytotoxic activity (IC 50 > 100 µM) on cancer cells, possessed moderate antibacterial effects against B. subtillis (MIC= 175 µM), moderate antidiarrheal and anti‐inflammatory effects, and minimal vasorelaxant effects. In the formalin test, DTA showed antinociceptive effects in both phases. In the acetic acid test, DTA showed antinociceptive activity (ED 50 = 50.2 ± 5.6 mg/kg) with potency similar to that of naproxen (NPX; ED 50 =33.7 ± 4.5 mg/kg) an effect blocked by naloxone implicating an opioid mechanism. DTA also exerted antidiarrheal activity and showed no sedative effects or changes in locomotor activity in mice. Drug Dev Res 78 : 340‐348, 2017. © 2017 Wiley Periodicals, Inc." @default.
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• W2738181886 date "2017-07-24" @default.
• W2738181886 modified "2023-10-14" @default.
• W2738181886 title "Antinociceptive Activity of Ent-Dihydrotucumanoic Acid Isolated from<i>Gymnosperma glutinosum</i>Spreng Less" @default.
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• W2738181886 doi "https://doi.org/10.1002/ddr.21397" @default.
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