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• W2738197480 abstract "The Biopharmaceutics Classification System (BCS) has been developed for human pharmaceutical compounds to predict oral drug absorption. A similar approach for evaluating in vitro data regarding dissolution, solubility, and permeability of veterinary oral dosage formulations has not been applied to predict oral absorption in animals. However, if reliable data can be generated, it may be possible to apply these principles to veterinary drugs. Before this can happen, obstacles must be overcome. Because of differences in anatomy and physiology between animals and people, extrapolations to veterinary drug formulations may not be applicable. Veterinary drug formulations also may differ in their size, excipient content, and use compared to human drug formulations. There is a clear need to examine the application of in vitro data regarding dissolution and permeability for product evaluation and regulatory decisions. This article and future scientific presentations will explore the potential for this application. Upon resolution of these questions and following appropriate adjustments to testing methods for permeability, solubility, and dissolution assessments, we will be able to apply, with confidence, BCS principles to oral formulations intended for use in dogs. We believe that the extrapolation of BCS principles to oral formulations for use in canines will prove to be an extremely valuable contribution to veterinary medicine. This Stimuli article on the potential applications of BCS to veterinary drugs was endorsed by the USP Veterinary Drugs Expert Committee. Reader comments about the suggested applications of in vitro solubility, permeability, dissolution data, and the BCS are invited." @default.
• W2738197480 created "2017-07-31" @default.
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• W2738197480 date "2013-01-01" @default.
• W2738197480 modified "2023-09-27" @default.
• W2738197480 title "Veterinary Application of In Vitro Dissolution Data and the Biopharmaceutics Classification System" @default.
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