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• W2738204313 endingPage "C459" @default.
• W2738204313 startingPage "C448" @default.
• W2738204313 abstract "Both zinc (Zn 2+ ) and reactive oxygen species (ROS) have been shown to accumulate during hypoxic-ischemic stress and play important roles in pathological processes. To understand the cross talk between the two of them, here we studied Zn 2+ and ROS accumulation by employing fluorescent probes in HeLa cells to further the understanding of the cause and effect relationship of these two important cellular signaling systems during chemical-ischemia, stimulated by oxygen and glucose deprivation (OGD). We observed two Zn 2+ rises that were divided into four phases in the course of 30 min of OGD. The first Zn 2+ rise was a transient, which was followed by a latent phase during which Zn 2+ levels recovered; however, levels remained above a basal level in most cells. The final phase was the second Zn 2+ rise, which reached a sustained plateau called Zn 2+ overload. Zn 2+ rises were not observed when Zn 2+ was removed by TPEN (a Zn 2+ chelator) or thapsigargin (depleting Zn 2+ from intracellular stores) treatment, indicating that Zn 2+ was from intracellular storage. Damaging mitochondria with FCCP significantly reduced the second Zn 2+ rise, indicating that the mitochondrial Zn 2+ accumulation contributes to Zn 2+ overload. We also detected two OGD-induced ROS rises. Two Zn 2+ rises preceded two ROS rises. Removal of Zn 2+ reduced or delayed OGD- and FCCP-induced ROS generation, indicating that Zn 2+ contributes to mitochondrial ROS generation. There was a Zn 2+ -induced increase in the functional component of NADPH oxidase, p47 phox , thus suggesting that NADPH oxidase may mediate Zn 2+ -induced ROS accumulation. We suggest a new mechanism of cross talk between Zn 2+ and mitochondrial ROS through positive feedback processes that eventually causes excessive free Zn 2+ and ROS accumulations during the course of ischemic stress." @default.
• W2738204313 created "2017-07-31" @default.
• W2738204313 creator A5007663503 @default.
• W2738204313 creator A5011389980 @default.
• W2738204313 creator A5065334594 @default.
• W2738204313 date "2017-10-01" @default.
• W2738204313 modified "2023-10-04" @default.
• W2738204313 title "Cross talk between increased intracellular zinc (Zn²⁺) and accumulation of reactive oxygen species in chemical ischemia" @default.
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• W2738204313 doi "https://doi.org/10.1152/ajpcell.00048.2017" @default.
• W2738204313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5668573" @default.
• W2738204313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28747335" @default.
• W2738204313 hasPublicationYear "2017" @default.
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