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- W2738237768 abstract "Oxidative stress due to the activation of a Nox2-containing NADPH oxidase is involved in Angiotensin II (AngII)-induced cardiovascular dysfunction. p47phox is a key regulatory subunit of Nox2. However, the role of p47phox in AngII-induced cardiac damage remains unclear. In this study, we used littermates of C57BL/6 wild-type (WT) and p47phox knockout (KO) mice (n=7) at the age of 10~12 months to investigate the effect of p47phox knockout on AngII-induced cardiac oxidative stress and hypertrophy. In WT mice, AngII infusion (1 mg/kg/day for 14 days) increased significantly the systolic blood pressure (SBP) from 127±13 to 172±11 mmHg, and this was accompanied with significant indication of cardiac hypertrophy (heart/body weight ratio increased ~17.9±0.1%) as compared to vehicle infused controls (p" @default.
- W2738237768 created "2017-07-31" @default.
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- W2738237768 date "2017-06-01" @default.
- W2738237768 modified "2023-09-24" @default.
- W2738237768 title "218 Knockout p47phox reduces angiotensin ii-induced cardiac oxidative stress and hypertrophy" @default.
- W2738237768 doi "https://doi.org/10.1136/heartjnl-2017-311726.216" @default.
- W2738237768 hasPublicationYear "2017" @default.
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