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- W2738244329 abstract "In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia." @default.
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- W2738244329 date "2010-01-01" @default.
- W2738244329 modified "2023-09-27" @default.
- W2738244329 title "Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia" @default.
- W2738244329 doi "https://doi.org/10.1515/nf-2010-0107" @default.
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