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• W27382752 abstract "There is considerable research to suggest that a neurobiological deficit might underpin obsessive-compulsive symptoms or be responsible for ObsessiveCompulsive Disorder (OCD). Deficits in executive functions are commonly reported in OCD and are believed to be mediated by the frontal lobes, the broad site of this neurobiological deficit. This thesis comprised of five studies that collectively attempt to address several key questions that required clarification within the executive function literature of OCD. Study 1 assessed executive functions of inhibition, set shifting, working memory, planning, and verbal fluency in OCD subjects (n = 20) compared to a clinical control group of Panic Disorder (PD, n = 20). OCD subjects exhibited deficits in all areas except planning and verbal fluency, in comparison to the PD group. Study 2 recruited an additional sample of Remitted OCD subjects (n = 20), and compared their performance to the original Symptomatic OCD group (n = 20) and PD control group (n = 20). It was found that executive function deficits were specific to OCD, and that symptom status did not affect the profile of these deficits. Study 3 adopted a longitudinal design and retested a sub-sample (n = 10) of Symptomatic OCD subjects that evidenced symptom remission. The stability of these deficits, even after remission, was confirmed in this study. In order to further clarify the nature of executive function deficits, particularly the role of inhibition and facilitation abnormalities in OCD, Study 4 assessed Symptomatic OCD (n = 20), Remitted OCD (n = 11), PD control (n = 20) and normal control subjects (n = 20), in a paradigm that separately studied inhibition and facilitation processes. It was found that OCD subjects displayed both excessive facilitation to primed responses and impaired inhibition to suppressed responses, in" @default.
• W27382752 created "2016-06-24" @default.
• W27382752 creator A5028638248 @default.
• W27382752 date "2003-01-01" @default.
• W27382752 modified "2023-09-27" @default.
• W27382752 title "Executive function deficits in obsessive-compulsive disorder: episode or trait markers" @default.
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