Matches in SemOpenAlex for { <https://semopenalex.org/work/W2738329081> ?p ?o ?g. }
- W2738329081 abstract "Abstract Developing seeds undergo coordinated physiological and morphological changes crucial for development of the embryo, dormancy and germination. The metabolic changes that occur during seed development are regulated by interconnected network of Transcription Factors (TFs) that regulate gene expression in a spatiotemporal manner. The complexity of these networks is such that the TFs that play key regulatory roles during seed development are largely unknown. In this study, we created a genome-scale regulatory network dedicated to describing regulation of biological processes within various compartments and developmental stages of Arabidopsis seeds. Differential network analysis revealed key TFs that rewire their targeting patterns specifically during seed development, many of which were already known, and a few novel ones that we verified experimentally. Our method shows that a high-resolution tissue-specific transcriptome dataset can be accurately modeled as a functional regulatory network predictive of related TFs. We provide an easy to use webtool using which researchers can upload a newly generated transcriptome and identify key TFs important to their dataset as well as gauge their regulatory effect on phenotypes observed in the experiment. We refer to this network as Seed Active Network (SANe) and made it accessible at https://plantstress-pereira.uark.edu/SANe/ . We anticipate SANe will facilitate the discovery of TFs yet unknown for their involvement in seed related metabolic pathways and provide an interface to generate new hypothesis for experimentation." @default.
- W2738329081 created "2017-07-31" @default.
- W2738329081 creator A5008919103 @default.
- W2738329081 creator A5011208416 @default.
- W2738329081 creator A5021785857 @default.
- W2738329081 creator A5031523626 @default.
- W2738329081 creator A5053907733 @default.
- W2738329081 date "2017-07-20" @default.
- W2738329081 modified "2023-10-16" @default.
- W2738329081 title "SANe: The Seed Active Network for Discovering Transcriptional Regulatory Programs of Seed Development" @default.
- W2738329081 cites W1270834676 @default.
- W2738329081 cites W1558369695 @default.
- W2738329081 cites W1669495645 @default.
- W2738329081 cites W1797459856 @default.
- W2738329081 cites W1955382403 @default.
- W2738329081 cites W1968231873 @default.
- W2738329081 cites W1976076241 @default.
- W2738329081 cites W1983922522 @default.
- W2738329081 cites W1985368543 @default.
- W2738329081 cites W1985942733 @default.
- W2738329081 cites W1986849266 @default.
- W2738329081 cites W1988047583 @default.
- W2738329081 cites W1989921625 @default.
- W2738329081 cites W1995015805 @default.
- W2738329081 cites W2001084806 @default.
- W2738329081 cites W2001191731 @default.
- W2738329081 cites W2002421918 @default.
- W2738329081 cites W2008003857 @default.
- W2738329081 cites W2011512348 @default.
- W2738329081 cites W2023580281 @default.
- W2738329081 cites W2025545161 @default.
- W2738329081 cites W2028639929 @default.
- W2738329081 cites W2034950225 @default.
- W2738329081 cites W2043774606 @default.
- W2738329081 cites W2044525257 @default.
- W2738329081 cites W2045299822 @default.
- W2738329081 cites W2045362835 @default.
- W2738329081 cites W2054454739 @default.
- W2738329081 cites W2060724738 @default.
- W2738329081 cites W2062352708 @default.
- W2738329081 cites W2063947061 @default.
- W2738329081 cites W2064340407 @default.
- W2738329081 cites W2064879183 @default.
- W2738329081 cites W2070133577 @default.
- W2738329081 cites W2071651798 @default.
- W2738329081 cites W2075925032 @default.
- W2738329081 cites W2076513103 @default.
- W2738329081 cites W2085512078 @default.
- W2738329081 cites W2095293504 @default.
- W2738329081 cites W2096451658 @default.
- W2738329081 cites W2096629558 @default.
- W2738329081 cites W2100401440 @default.
- W2738329081 cites W2100945610 @default.
- W2738329081 cites W2102074241 @default.
- W2738329081 cites W2103205896 @default.
- W2738329081 cites W2104864984 @default.
- W2738329081 cites W2105259668 @default.
- W2738329081 cites W2107617648 @default.
- W2738329081 cites W2108392737 @default.
- W2738329081 cites W2109956481 @default.
- W2738329081 cites W2113708398 @default.
- W2738329081 cites W2114256580 @default.
- W2738329081 cites W2115003883 @default.
- W2738329081 cites W2117199973 @default.
- W2738329081 cites W2118022469 @default.
- W2738329081 cites W2121490038 @default.
- W2738329081 cites W2123116714 @default.
- W2738329081 cites W2127632851 @default.
- W2738329081 cites W2127968944 @default.
- W2738329081 cites W2128860085 @default.
- W2738329081 cites W2129243798 @default.
- W2738329081 cites W2129870213 @default.
- W2738329081 cites W2131935563 @default.
- W2738329081 cites W2138438425 @default.
- W2738329081 cites W2142389038 @default.
- W2738329081 cites W2147660871 @default.
- W2738329081 cites W2148750035 @default.
- W2738329081 cites W2150368598 @default.
- W2738329081 cites W2152896172 @default.
- W2738329081 cites W2156640201 @default.
- W2738329081 cites W2158287613 @default.
- W2738329081 cites W2160313295 @default.
- W2738329081 cites W2161409973 @default.
- W2738329081 cites W2161922815 @default.
- W2738329081 cites W2162781740 @default.
- W2738329081 cites W2166671294 @default.
- W2738329081 cites W2168104796 @default.
- W2738329081 cites W2169336947 @default.
- W2738329081 cites W2170989872 @default.
- W2738329081 cites W2177462375 @default.
- W2738329081 cites W2183047642 @default.
- W2738329081 cites W2190616585 @default.
- W2738329081 cites W2208364268 @default.
- W2738329081 cites W2289718006 @default.
- W2738329081 cites W2345688904 @default.
- W2738329081 cites W2473710394 @default.
- W2738329081 cites W2484866312 @default.
- W2738329081 cites W2513809037 @default.
- W2738329081 cites W2515276442 @default.
- W2738329081 cites W2524419346 @default.