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- W2738376688 abstract "Preservation of the pancreatic β-cell population is required for the development of therapies for diabetes, which is caused by a decrease in β-cells. Here, we demonstrate the antidiabetic effects of substance P (SP) in type 1 diabetes (T1D) mice induced with streptozotocin. SP enhanced the compensatory proliferation of β-cells in order to restore β-cells in response to acute injury induced by a single high-dose of streptozotocin. However, SP affected neither the basal proliferation of β-cells nor their apoptosis. In vitro studies by using the INS-1 pancreatic β-cell line showed that SP mediated the increase in the proliferation of β-cells via the activation of Akt. Chronic systemic treatment with SP restored the mass of β-cells and inhibited insulitis in T1D mice induced with multiple low-doses of streptozotocin. Therefore, systemic treatment with SP may be a promising therapeutic strategy for treating diabetes in patients with loss of functional β-cells." @default.
- W2738376688 created "2017-07-31" @default.
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- W2738376688 date "2017-09-01" @default.
- W2738376688 modified "2023-10-03" @default.
- W2738376688 title "Substance P preserves pancreatic β-cells in streptozotocin-induced type 1 diabetic mice" @default.
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- W2738376688 doi "https://doi.org/10.1016/j.bbrc.2017.07.142" @default.
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