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- W2738424306 abstract "Sepsis is a frequent condition, defined as life-threatening organ dysfunction associated with a severe infection. 1 Singer M Deutschman CS Seymour CW et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016; 315: 801-810 Crossref PubMed Scopus (11755) Google Scholar Over the past three decades, progress in understanding of the pathophysiology of sepsis has led to the development of a large number of potential new therapies for sepsis. Many of these underwent preclinical testing with promising results and moved into clinical trials with the hope that they would improve survival from sepsis. Some of these interventions successfully passed early phase trials and underwent testing in large multicentre randomised controlled trials. However, here the success story stopped, with none of the agents successfully shown to improve outcomes. Sepsis treatment is, therefore, still largely based on antibiotic therapy, source control, and haemodynamic resuscitation. 2 Rhodes A Evans LE Alhazzani W et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med. 2017; 45: 486-552 Crossref PubMed Scopus (1910) Google Scholar The fact that so many attempts to improve sepsis outcomes have failed must prompt a rethink of clinical trial design and conduct in this field. We will detail some of the reasons why so many trials were negative and make some suggestions as to how to move forward." @default.
- W2738424306 created "2017-07-31" @default.
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- W2738424306 date "2017-08-01" @default.
- W2738424306 modified "2023-10-18" @default.
- W2738424306 title "Clinical trial research in focus: rethinking trials in sepsis" @default.
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- W2738424306 doi "https://doi.org/10.1016/s2213-2600(17)30268-0" @default.
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