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- W2738511212 abstract "A simple and cost effective spectrophotometric method was described for the determination of Imipenem in pure form and in pharmaceutical formulations. The method is based on the formation of pink colored chromogen when the drug reacts with N-Bromo Succinamide(NBS) reagent and Celestin Blue(CB) in acidic medium. The colored species has an absorption maximum at 525 nm for Imipenem and obeys beer’s law in the concentration range 0.008 – 0.048 µg/mL of Imipenem. The apparent molar absorptivity was 53x10 -3 and sandell’s sensitivity was 7x10 -3 . The slope was 1.805 ± 0.02774 and intercept of the equation of the regression line are 0.02964 ± 0.02001. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of Imipenem in pharmaceutical formulations." @default.
- W2738511212 created "2017-07-31" @default.
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- W2738511212 date "2014-01-01" @default.
- W2738511212 modified "2023-09-27" @default.
- W2738511212 title "A NOVAL METHOD DEVELOPMENT AND VALIDATION OF IMIPENEM IN BULK AND INJECTION FORMULATIONS BY SPECTROPHOTOMETRIC AND RP-HPLC METHODS" @default.
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