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- W2738548892 endingPage "1013" @default.
- W2738548892 startingPage "1013" @default.
- W2738548892 abstract "The development, maturation and regeneration of Schwann cells (SCs), the main glial cells of the peripheral nervous system, require the coordinate and complementary interaction among several factors, signals and intracellular pathways. These regulatory molecules consist of integrins, neuregulins, growth factors, hormones, neurotransmitters, as well as entire intracellular pathways including protein-kinase A, C, Akt, Erk/MAPK, Hippo, mTOR, etc. For instance, Hippo pathway is overall involved in proliferation, apoptosis, regeneration and organ size control, being crucial in cancer proliferation process. In SCs, Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges. Recently, among factors regulating SCs, also the signaling intermediates Src tyrosine kinase and focal adhesion kinase (FAK) proved relevant for SC fate, participating in the regulation of adhesion, motility, migration and in vitro myelination. In SCs, the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone, thus corroborating the importance of this steroid in the control of SC maturation. In this review, we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental, mature and regenerative states" @default.
- W2738548892 created "2017-07-31" @default.
- W2738548892 creator A5002963265 @default.
- W2738548892 creator A5033400546 @default.
- W2738548892 creator A5054471634 @default.
- W2738548892 creator A5056928470 @default.
- W2738548892 creator A5067614773 @default.
- W2738548892 creator A5080844847 @default.
- W2738548892 date "2017-01-01" @default.
- W2738548892 modified "2023-10-14" @default.
- W2738548892 title "Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways" @default.
- W2738548892 cites W1590619320 @default.
- W2738548892 cites W1598129734 @default.
- W2738548892 cites W1602822799 @default.
- W2738548892 cites W1771908377 @default.
- W2738548892 cites W1785533687 @default.
- W2738548892 cites W1869105551 @default.
- W2738548892 cites W1938794984 @default.
- W2738548892 cites W1959834892 @default.
- W2738548892 cites W1960355435 @default.
- W2738548892 cites W1964157884 @default.
- W2738548892 cites W1965375903 @default.
- W2738548892 cites W1965571714 @default.
- W2738548892 cites W1966516467 @default.
- W2738548892 cites W1969552240 @default.
- W2738548892 cites W1973009368 @default.
- W2738548892 cites W1973976893 @default.
- W2738548892 cites W1975370877 @default.
- W2738548892 cites W1975560014 @default.
- W2738548892 cites W1975692560 @default.
- W2738548892 cites W1983458178 @default.
- W2738548892 cites W1987226347 @default.
- W2738548892 cites W1988301645 @default.
- W2738548892 cites W1988386079 @default.
- W2738548892 cites W1989454103 @default.
- W2738548892 cites W1989963039 @default.
- W2738548892 cites W1995160678 @default.
- W2738548892 cites W1995717532 @default.
- W2738548892 cites W1996109640 @default.
- W2738548892 cites W1998079931 @default.
- W2738548892 cites W1998236920 @default.
- W2738548892 cites W2000129128 @default.
- W2738548892 cites W2000953663 @default.
- W2738548892 cites W2004480757 @default.
- W2738548892 cites W2004637658 @default.
- W2738548892 cites W2005067021 @default.
- W2738548892 cites W2012255717 @default.
- W2738548892 cites W2022782261 @default.
- W2738548892 cites W2025431459 @default.
- W2738548892 cites W2028934778 @default.
- W2738548892 cites W2029394013 @default.
- W2738548892 cites W2030611592 @default.
- W2738548892 cites W2030860399 @default.
- W2738548892 cites W2033545707 @default.
- W2738548892 cites W2033778954 @default.
- W2738548892 cites W2035074539 @default.
- W2738548892 cites W2038597322 @default.
- W2738548892 cites W2039055179 @default.
- W2738548892 cites W2041648860 @default.
- W2738548892 cites W2042922488 @default.
- W2738548892 cites W2050088647 @default.
- W2738548892 cites W2051179106 @default.
- W2738548892 cites W2052150897 @default.
- W2738548892 cites W2053582875 @default.
- W2738548892 cites W2062483095 @default.
- W2738548892 cites W2063063761 @default.
- W2738548892 cites W2064050813 @default.
- W2738548892 cites W2070879574 @default.
- W2738548892 cites W2079103153 @default.
- W2738548892 cites W2085384084 @default.
- W2738548892 cites W2087766778 @default.
- W2738548892 cites W2091439778 @default.
- W2738548892 cites W2092322285 @default.
- W2738548892 cites W2093021491 @default.
- W2738548892 cites W2093229003 @default.
- W2738548892 cites W2093423091 @default.
- W2738548892 cites W2094074316 @default.
- W2738548892 cites W2094122805 @default.
- W2738548892 cites W2094895636 @default.
- W2738548892 cites W2096027130 @default.
- W2738548892 cites W2096948793 @default.
- W2738548892 cites W2097473353 @default.
- W2738548892 cites W2098628437 @default.
- W2738548892 cites W2099112212 @default.
- W2738548892 cites W2100704394 @default.
- W2738548892 cites W2105356859 @default.
- W2738548892 cites W2106321953 @default.
- W2738548892 cites W2113460739 @default.
- W2738548892 cites W2113551776 @default.
- W2738548892 cites W2114648573 @default.
- W2738548892 cites W2115328665 @default.
- W2738548892 cites W2115819535 @default.
- W2738548892 cites W2120442017 @default.
- W2738548892 cites W2121611210 @default.
- W2738548892 cites W2123046057 @default.
- W2738548892 cites W2126712555 @default.
- W2738548892 cites W2131020789 @default.
- W2738548892 cites W2134629457 @default.