Matches in SemOpenAlex for { <https://semopenalex.org/work/W2738720886> ?p ?o ?g. }
- W2738720886 abstract "Abstract Clathrin-dependent and -independent pathways contribute for β1-integrin endocytosis. This study defines a tubular membrane clathrin-independent endocytic network, induced with the calmodulin inhibitor W13, for β1-integrin internalization. This pathway is dependent on increased phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2 ) levels and dynamin activity at the plasma membrane. Exogenous addition of PI(4,5)P 2 or phosphatidylinositol-4-phosphate 5-kinase (PIP5K) expression mimicked W13-generated-tubules which are inhibited by active Rac1. Therefore, the molecular mechanisms downstream of Rac1, that controls this plasma membrane tubulation, were analyzed biochemically and by the expression of different Rac1 mutants. The results indicate that phospholipase C and ROCK1 are the main Rac1 effectors that impair plasma membrane invagination and tubule formation, essentially by decreasing PI(4,5)P 2 levels and promoting cortical actomyosin assembly respectively. Interestingly, among the plethora of proteins that participate in membrane remodeling, this study revealed that ROCK1, the well-known downstream RhoA effector, has an important role in Rac1 regulation of actomyosin at the cell cortex. This study provides new insights into Rac1 functioning on plasma membrane dynamics combining phosphatidylinositides and cytoskeleton regulation." @default.
- W2738720886 created "2017-07-31" @default.
- W2738720886 creator A5000057658 @default.
- W2738720886 creator A5022727157 @default.
- W2738720886 creator A5027752685 @default.
- W2738720886 creator A5031514803 @default.
- W2738720886 creator A5042164155 @default.
- W2738720886 creator A5052829580 @default.
- W2738720886 creator A5057960764 @default.
- W2738720886 creator A5064503855 @default.
- W2738720886 date "2017-07-31" @default.
- W2738720886 modified "2023-10-13" @default.
- W2738720886 title "ROCK1 is a novel Rac1 effector to regulate tubular endocytic membrane formation during clathrin-independent endocytosis" @default.
- W2738720886 cites W1520020505 @default.
- W2738720886 cites W1568586029 @default.
- W2738720886 cites W1580997375 @default.
- W2738720886 cites W1663246596 @default.
- W2738720886 cites W1852430844 @default.
- W2738720886 cites W1903683922 @default.
- W2738720886 cites W1910518513 @default.
- W2738720886 cites W1965940344 @default.
- W2738720886 cites W1966482564 @default.
- W2738720886 cites W1967007326 @default.
- W2738720886 cites W1970115525 @default.
- W2738720886 cites W1972812883 @default.
- W2738720886 cites W1973089936 @default.
- W2738720886 cites W1974319248 @default.
- W2738720886 cites W1975572503 @default.
- W2738720886 cites W1976896684 @default.
- W2738720886 cites W1981431290 @default.
- W2738720886 cites W1981861833 @default.
- W2738720886 cites W1983443986 @default.
- W2738720886 cites W1984994493 @default.
- W2738720886 cites W1986238621 @default.
- W2738720886 cites W1993721193 @default.
- W2738720886 cites W1996031315 @default.
- W2738720886 cites W1996107157 @default.
- W2738720886 cites W1996453362 @default.
- W2738720886 cites W1996968937 @default.
- W2738720886 cites W1997087774 @default.
- W2738720886 cites W1998846966 @default.
- W2738720886 cites W1999237513 @default.
- W2738720886 cites W2000678571 @default.
- W2738720886 cites W2001674490 @default.
- W2738720886 cites W2002410732 @default.
- W2738720886 cites W2006689028 @default.
- W2738720886 cites W2007985534 @default.
- W2738720886 cites W2008570998 @default.
- W2738720886 cites W2010781630 @default.
- W2738720886 cites W2014405796 @default.
- W2738720886 cites W2014840069 @default.
- W2738720886 cites W2019731805 @default.
- W2738720886 cites W2021908043 @default.
- W2738720886 cites W2024428899 @default.
- W2738720886 cites W2030029307 @default.
- W2738720886 cites W2031874417 @default.
- W2738720886 cites W2032295238 @default.
- W2738720886 cites W2032372404 @default.
- W2738720886 cites W2034971176 @default.
- W2738720886 cites W2039805756 @default.
- W2738720886 cites W2041724231 @default.
- W2738720886 cites W2043899728 @default.
- W2738720886 cites W2047109217 @default.
- W2738720886 cites W2050291058 @default.
- W2738720886 cites W2054044658 @default.
- W2738720886 cites W2061228001 @default.
- W2738720886 cites W2063575573 @default.
- W2738720886 cites W2063912602 @default.
- W2738720886 cites W2066172896 @default.
- W2738720886 cites W2067671651 @default.
- W2738720886 cites W2067861954 @default.
- W2738720886 cites W2069597305 @default.
- W2738720886 cites W2071199281 @default.
- W2738720886 cites W2071691594 @default.
- W2738720886 cites W2072751436 @default.
- W2738720886 cites W2075100878 @default.
- W2738720886 cites W2075887159 @default.
- W2738720886 cites W2077603983 @default.
- W2738720886 cites W2080989887 @default.
- W2738720886 cites W2081631747 @default.
- W2738720886 cites W2086271423 @default.
- W2738720886 cites W2086482690 @default.
- W2738720886 cites W2088603460 @default.
- W2738720886 cites W2088954489 @default.
- W2738720886 cites W2089003221 @default.
- W2738720886 cites W2090469070 @default.
- W2738720886 cites W2095751049 @default.
- W2738720886 cites W2096873347 @default.
- W2738720886 cites W2105083581 @default.
- W2738720886 cites W2109208017 @default.
- W2738720886 cites W2112634792 @default.
- W2738720886 cites W2112668385 @default.
- W2738720886 cites W2114902150 @default.
- W2738720886 cites W2118060829 @default.
- W2738720886 cites W2119809698 @default.
- W2738720886 cites W2123082102 @default.
- W2738720886 cites W2129123695 @default.
- W2738720886 cites W2130779504 @default.
- W2738720886 cites W2133337899 @default.
- W2738720886 cites W2137567442 @default.