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- W2738721638 endingPage "427" @default.
- W2738721638 startingPage "421" @default.
- W2738721638 abstract "Radiotherapy is an attractive treatment option for older adults, especially where surgery and chemotherapy pose too great a risk. Radiotherapy toxicity may be divided into acute/early and late effects of treatment. The latter may have limited relevance to an older patient with competing causes of mortality due to significant comorbidity. Altered fractionation regimes have been employed in numerous sites, with no significant toxicity impact. These offer greater convenience in the elderly, especially those with limited social support or in active caregiving roles. As radiotherapy toxicity is site specific, it's important to assess baseline function via Comprehensive Geriatric Assessment (CGA), and any pre-existing comorbidities that may influence toxicity. With modern radiotherapy technology and capabilities, these are less of an issue and radiotherapy is a very suitable treatment option for the older adult. When evaluating the literature on toxicity in older patients, it's important to recognise that older studies do not represent modern day radiotherapy techniques and capabilities. Advanced technology may simultaneously deliver enhanced target coverage and reduced toxicity. More research is required related to the predictive power of CGA in linking radiotherapy toxicity to frailty. What little evidence exists shows that CGA has a role in treatment of older patients with radiotherapy and that, in general, radiotherapy appears to be well tolerated in older adults. The purpose of this review is to provide a broad overview of the mechanisms of normal tissue reactions to radiotherapy and how radiation induced toxicity may affect older patients." @default.
- W2738721638 created "2017-07-31" @default.
- W2738721638 creator A5029901257 @default.
- W2738721638 creator A5048721022 @default.
- W2738721638 creator A5082069303 @default.
- W2738721638 date "2017-11-01" @default.
- W2738721638 modified "2023-10-16" @default.
- W2738721638 title "Assessment and management of radiotherapy induced toxicity in older patients" @default.
- W2738721638 cites W1238818623 @default.
- W2738721638 cites W1551313213 @default.
- W2738721638 cites W1559051003 @default.
- W2738721638 cites W1944505717 @default.
- W2738721638 cites W1975424772 @default.
- W2738721638 cites W1980977417 @default.
- W2738721638 cites W1982853521 @default.
- W2738721638 cites W1983558676 @default.
- W2738721638 cites W1984502501 @default.
- W2738721638 cites W1987760772 @default.
- W2738721638 cites W1990510898 @default.
- W2738721638 cites W1995679745 @default.
- W2738721638 cites W1999943670 @default.
- W2738721638 cites W2002170698 @default.
- W2738721638 cites W2004154883 @default.
- W2738721638 cites W2011690741 @default.
- W2738721638 cites W2011974825 @default.
- W2738721638 cites W2016972400 @default.
- W2738721638 cites W2017672654 @default.
- W2738721638 cites W2024046142 @default.
- W2738721638 cites W2024107960 @default.
- W2738721638 cites W2024492396 @default.
- W2738721638 cites W2043468165 @default.
- W2738721638 cites W2045805729 @default.
- W2738721638 cites W2045965872 @default.
- W2738721638 cites W2046701188 @default.
- W2738721638 cites W2058720365 @default.
- W2738721638 cites W2063247340 @default.
- W2738721638 cites W2063861120 @default.
- W2738721638 cites W2072712595 @default.
- W2738721638 cites W2073691329 @default.
- W2738721638 cites W2074048861 @default.
- W2738721638 cites W2082687472 @default.
- W2738721638 cites W2085082111 @default.
- W2738721638 cites W2086694546 @default.
- W2738721638 cites W2088464819 @default.
- W2738721638 cites W2089257078 @default.
- W2738721638 cites W2092064202 @default.
- W2738721638 cites W2094044539 @default.
- W2738721638 cites W2094778693 @default.
- W2738721638 cites W2100774708 @default.
- W2738721638 cites W2100787775 @default.
- W2738721638 cites W2101112840 @default.
- W2738721638 cites W2101751898 @default.
- W2738721638 cites W2104701073 @default.
- W2738721638 cites W2105940636 @default.
- W2738721638 cites W2107243894 @default.
- W2738721638 cites W2116931764 @default.
- W2738721638 cites W2122428334 @default.
- W2738721638 cites W2123312185 @default.
- W2738721638 cites W2123927174 @default.
- W2738721638 cites W2127471618 @default.
- W2738721638 cites W2130514725 @default.
- W2738721638 cites W2131423565 @default.
- W2738721638 cites W2137642415 @default.
- W2738721638 cites W2137775935 @default.
- W2738721638 cites W2140110477 @default.
- W2738721638 cites W2141944007 @default.
- W2738721638 cites W2144574555 @default.
- W2738721638 cites W2148152153 @default.
- W2738721638 cites W2149386818 @default.
- W2738721638 cites W2151769574 @default.
- W2738721638 cites W2152609192 @default.
- W2738721638 cites W2154375587 @default.
- W2738721638 cites W2154593851 @default.
- W2738721638 cites W2154811939 @default.
- W2738721638 cites W2156016749 @default.
- W2738721638 cites W2156875127 @default.
- W2738721638 cites W2158633858 @default.
- W2738721638 cites W2159296014 @default.
- W2738721638 cites W2160293835 @default.
- W2738721638 cites W2161902281 @default.
- W2738721638 cites W2162605078 @default.
- W2738721638 cites W2164059021 @default.
- W2738721638 cites W2164753697 @default.
- W2738721638 cites W2167600867 @default.
- W2738721638 cites W2169076544 @default.
- W2738721638 cites W2182266844 @default.
- W2738721638 cites W2254368272 @default.
- W2738721638 cites W2287611703 @default.
- W2738721638 cites W2292449653 @default.
- W2738721638 cites W2306163090 @default.
- W2738721638 cites W2320761214 @default.
- W2738721638 cites W2331849216 @default.
- W2738721638 cites W2337065089 @default.
- W2738721638 cites W2424391321 @default.
- W2738721638 cites W2435402740 @default.
- W2738721638 cites W2515426561 @default.
- W2738721638 cites W2525635051 @default.
- W2738721638 cites W2528260117 @default.