Matches in SemOpenAlex for { <https://semopenalex.org/work/W2738767347> ?p ?o ?g. }
- W2738767347 abstract "ABSTRACT When Drosophila flies feed on Pseudomonas aeruginosa strain PA14, some bacteria cross the intestinal barrier and start proliferating inside the hemocoel. This process is limited by hemocytes through phagocytosis. We have previously shown that the PA14 quorum-sensing regulator RhlR is required for these bacteria to elude the cellular immune response. RhlI synthesizes the auto-inducer signal that activates RhlR. Here, we compare the null mutant phenotypes of rhlR and rhlI in a variety of infection assays in Drosophila and in the nematode Caenorhabditis elegans . Surprisingly, in Drosophila , unlike ΔrhlR mutants, ΔrhlI mutants are only modestly attenuated for virulence and are poorly phagocytosed and opsonized in a Thioester-containing Protein4-dependent manner. Likewise, Δ rhlI but not Δ rhlR mutants colonize the digestive tract of C. elegans and kill it as efficiently as wild-type PA14. Thus, RhlR has an RhlI-independent function in eluding detection or counter-acting the action of the immune system. In contrast to the intestinal infection model, Tep4 mutant flies are more resistant to PA14 in a septic injury model, which also depends on rhlR . Thus, the Tep4 putative opsonin can either be protective or detrimental to host defense depending on the infection route." @default.
- W2738767347 created "2017-07-31" @default.
- W2738767347 creator A5004845998 @default.
- W2738767347 creator A5015127544 @default.
- W2738767347 creator A5023090622 @default.
- W2738767347 creator A5024801222 @default.
- W2738767347 creator A5027836060 @default.
- W2738767347 creator A5033332432 @default.
- W2738767347 creator A5033700677 @default.
- W2738767347 creator A5048379858 @default.
- W2738767347 creator A5068867749 @default.
- W2738767347 creator A5084123261 @default.
- W2738767347 creator A5091268228 @default.
- W2738767347 date "2017-07-19" @default.
- W2738767347 modified "2023-09-25" @default.
- W2738767347 title "RhlR, but not RhlI, allowsP. aeruginosabacteria to evadeDrosophilaTep4-mediated opsonization" @default.
- W2738767347 cites W1496487857 @default.
- W2738767347 cites W1550480750 @default.
- W2738767347 cites W1561229372 @default.
- W2738767347 cites W1747868356 @default.
- W2738767347 cites W1930952977 @default.
- W2738767347 cites W1945092145 @default.
- W2738767347 cites W1964573208 @default.
- W2738767347 cites W1967325223 @default.
- W2738767347 cites W1970762617 @default.
- W2738767347 cites W1973430111 @default.
- W2738767347 cites W1988248862 @default.
- W2738767347 cites W1989719456 @default.
- W2738767347 cites W1996858055 @default.
- W2738767347 cites W1998741829 @default.
- W2738767347 cites W1999503885 @default.
- W2738767347 cites W2003156936 @default.
- W2738767347 cites W2004732995 @default.
- W2738767347 cites W2005222994 @default.
- W2738767347 cites W2009469402 @default.
- W2738767347 cites W2012387790 @default.
- W2738767347 cites W2015088566 @default.
- W2738767347 cites W2021901129 @default.
- W2738767347 cites W2024940746 @default.
- W2738767347 cites W2035782757 @default.
- W2738767347 cites W2036868716 @default.
- W2738767347 cites W2052104837 @default.
- W2738767347 cites W2053095874 @default.
- W2738767347 cites W2055807373 @default.
- W2738767347 cites W2057301646 @default.
- W2738767347 cites W2068805793 @default.
- W2738767347 cites W2073058435 @default.
- W2738767347 cites W2073522307 @default.
- W2738767347 cites W2084630938 @default.
- W2738767347 cites W2085034589 @default.
- W2738767347 cites W2089073018 @default.
- W2738767347 cites W2090964435 @default.
- W2738767347 cites W2091658350 @default.
- W2738767347 cites W2101021939 @default.
- W2738767347 cites W2102549002 @default.
- W2738767347 cites W2112783898 @default.
- W2738767347 cites W2113177287 @default.
- W2738767347 cites W2130204542 @default.
- W2738767347 cites W2136457322 @default.
- W2738767347 cites W2137215017 @default.
- W2738767347 cites W2152457344 @default.
- W2738767347 cites W2160037478 @default.
- W2738767347 cites W2162487010 @default.
- W2738767347 cites W2165407655 @default.
- W2738767347 cites W2166134293 @default.
- W2738767347 cites W2166816492 @default.
- W2738767347 cites W2167669748 @default.
- W2738767347 cites W2168755417 @default.
- W2738767347 cites W2171527366 @default.
- W2738767347 cites W2416060526 @default.
- W2738767347 cites W2534977816 @default.
- W2738767347 cites W2555970702 @default.
- W2738767347 cites W2560511161 @default.
- W2738767347 cites W2582093708 @default.
- W2738767347 cites W2612656630 @default.
- W2738767347 cites W2728504353 @default.
- W2738767347 cites W2735053732 @default.
- W2738767347 doi "https://doi.org/10.1101/165530" @default.
- W2738767347 hasPublicationYear "2017" @default.
- W2738767347 type Work @default.
- W2738767347 sameAs 2738767347 @default.
- W2738767347 citedByCount "0" @default.
- W2738767347 crossrefType "posted-content" @default.
- W2738767347 hasAuthorship W2738767347A5004845998 @default.
- W2738767347 hasAuthorship W2738767347A5015127544 @default.
- W2738767347 hasAuthorship W2738767347A5023090622 @default.
- W2738767347 hasAuthorship W2738767347A5024801222 @default.
- W2738767347 hasAuthorship W2738767347A5027836060 @default.
- W2738767347 hasAuthorship W2738767347A5033332432 @default.
- W2738767347 hasAuthorship W2738767347A5033700677 @default.
- W2738767347 hasAuthorship W2738767347A5048379858 @default.
- W2738767347 hasAuthorship W2738767347A5068867749 @default.
- W2738767347 hasAuthorship W2738767347A5084123261 @default.
- W2738767347 hasAuthorship W2738767347A5091268228 @default.
- W2738767347 hasBestOaLocation W27387673471 @default.
- W2738767347 hasConcept C104317684 @default.
- W2738767347 hasConcept C118687296 @default.
- W2738767347 hasConcept C143065580 @default.
- W2738767347 hasConcept C2777637488 @default.
- W2738767347 hasConcept C2780104201 @default.