Matches in SemOpenAlex for { <https://semopenalex.org/work/W2738816679> ?p ?o ?g. }
- W2738816679 endingPage "56" @default.
- W2738816679 startingPage "37" @default.
- W2738816679 abstract "Alzheimer's disease (AD) is the most common form of dementia. The development of assay technologies able to diagnose early-stage AD is important. Blood tests to detect biomarkers, such as amyloid and total Tau protein, are among the most promising diagnostic methods due to their low cost, low risk, and ease of operation. However, such biomarkers in blood occur at extremely low levels and are difficult to detect precisely. In the early 2000s, a highly sensitive assay technology, immunomagnetic reduction (IMR), was developed. IMR involves the use of antibody-functionalized magnetic nanoparticles dispersed in aqueous solution. The concentrations of detected molecules are converted to reductions in the ac magnetic susceptibility of this reagent due to the association between the magnetic nanoparticles and molecules. To achieve ultra-high sensitivity, a high-Tc superconducting-quantum-interference-device (SQUID) ac magnetosusceptometer was designed and applied to detect the tiny reduction in the ac magnetic susceptibility of the reagent. Currently, a 36-channeled high-Tc SQUID-based ac magnetosusceptometer is available. Using the reagent and this analyzer, extremely low concentrations of amyloid and total Tau protein in human plasma could be detected. Further, the feasibility of identifying subjects in early-stage AD via assaying plasma amyloid and total Tau protein is demonstrated. The results show a diagnostic accuracy for prodromal AD higher than 80% and reveal the possibility of screening for early-stage AD using SQUID-based IMR." @default.
- W2738816679 created "2017-07-31" @default.
- W2738816679 creator A5028009522 @default.
- W2738816679 creator A5065273987 @default.
- W2738816679 creator A5067018066 @default.
- W2738816679 creator A5069234066 @default.
- W2738816679 date "2017-07-01" @default.
- W2738816679 modified "2023-10-12" @default.
- W2738816679 title "Detection of Plasma Biomarkers Using Immunomagnetic Reduction: A Promising Method for the Early Diagnosis of Alzheimer’s Disease" @default.
- W2738816679 cites W1486032953 @default.
- W2738816679 cites W1495649094 @default.
- W2738816679 cites W1529625404 @default.
- W2738816679 cites W1532594816 @default.
- W2738816679 cites W1567490604 @default.
- W2738816679 cites W1611407165 @default.
- W2738816679 cites W1616122655 @default.
- W2738816679 cites W1934350316 @default.
- W2738816679 cites W1963599567 @default.
- W2738816679 cites W1964472291 @default.
- W2738816679 cites W1965352829 @default.
- W2738816679 cites W1967075875 @default.
- W2738816679 cites W1967082239 @default.
- W2738816679 cites W1969713976 @default.
- W2738816679 cites W1970821891 @default.
- W2738816679 cites W1974604086 @default.
- W2738816679 cites W1979492567 @default.
- W2738816679 cites W1984000125 @default.
- W2738816679 cites W1987909254 @default.
- W2738816679 cites W1991461818 @default.
- W2738816679 cites W2002181764 @default.
- W2738816679 cites W2007350172 @default.
- W2738816679 cites W2009849318 @default.
- W2738816679 cites W2010686441 @default.
- W2738816679 cites W2017330669 @default.
- W2738816679 cites W2017859333 @default.
- W2738816679 cites W2018715207 @default.
- W2738816679 cites W2022810388 @default.
- W2738816679 cites W2032324238 @default.
- W2738816679 cites W2036994773 @default.
- W2738816679 cites W2041330307 @default.
- W2738816679 cites W2043068046 @default.
- W2738816679 cites W2044597283 @default.
- W2738816679 cites W2050607653 @default.
- W2738816679 cites W2053116497 @default.
- W2738816679 cites W2058723245 @default.
- W2738816679 cites W2064963539 @default.
- W2738816679 cites W2068837024 @default.
- W2738816679 cites W2075193321 @default.
- W2738816679 cites W2079472057 @default.
- W2738816679 cites W2082396808 @default.
- W2738816679 cites W2091036612 @default.
- W2738816679 cites W2091253248 @default.
- W2738816679 cites W2095963715 @default.
- W2738816679 cites W2097870720 @default.
- W2738816679 cites W2100377941 @default.
- W2738816679 cites W2103346709 @default.
- W2738816679 cites W2103440561 @default.
- W2738816679 cites W2103575664 @default.
- W2738816679 cites W2104048700 @default.
- W2738816679 cites W2106839031 @default.
- W2738816679 cites W2116451919 @default.
- W2738816679 cites W2122328291 @default.
- W2738816679 cites W2125396574 @default.
- W2738816679 cites W2131328232 @default.
- W2738816679 cites W2131830246 @default.
- W2738816679 cites W2134815580 @default.
- W2738816679 cites W2135957529 @default.
- W2738816679 cites W2138841544 @default.
- W2738816679 cites W2143461767 @default.
- W2738816679 cites W2149618018 @default.
- W2738816679 cites W2155571084 @default.
- W2738816679 cites W2156220037 @default.
- W2738816679 cites W2158766477 @default.
- W2738816679 cites W2160591264 @default.
- W2738816679 cites W2162997750 @default.
- W2738816679 cites W2163641346 @default.
- W2738816679 cites W2320490732 @default.
- W2738816679 cites W2325781902 @default.
- W2738816679 cites W2353776455 @default.
- W2738816679 cites W2408989194 @default.
- W2738816679 cites W2409038960 @default.
- W2738816679 cites W2411946435 @default.
- W2738816679 cites W2414917913 @default.
- W2738816679 cites W4210975612 @default.
- W2738816679 cites W4383871900 @default.
- W2738816679 doi "https://doi.org/10.1007/s40120-017-0075-7" @default.
- W2738816679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5520821" @default.
- W2738816679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28733955" @default.
- W2738816679 hasPublicationYear "2017" @default.
- W2738816679 type Work @default.
- W2738816679 sameAs 2738816679 @default.
- W2738816679 citedByCount "53" @default.
- W2738816679 countsByYear W27388166792017 @default.
- W2738816679 countsByYear W27388166792018 @default.
- W2738816679 countsByYear W27388166792019 @default.
- W2738816679 countsByYear W27388166792020 @default.
- W2738816679 countsByYear W27388166792021 @default.
- W2738816679 countsByYear W27388166792022 @default.