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- W2738948082 abstract "Two new lactone-containing selaginellins T and U (1 and 2) together with eleven known selaginellin derivatives (3 and 7-16) were isolated from the whole plant of Selaginella tamariscina. The structure of tautomeric selaginellin U along with its biogenetic pathway was confirmed and proposed by a cross-validation of the semisynthesis of compound 4 from selaginellin (3) and derivation from 2 to 4. Additionally, compounds 3, 13 and 16 exhibited good inhibitory activities against β-site amyloid precursor protein cleaving enzyme 1 (BACE1) with IC50 values of 81.17, 51.13 and 48.89 µM, respectively." @default.
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- W2738948082 date "2017-07-01" @default.
- W2738948082 modified "2023-10-18" @default.
- W2738948082 title "A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from <i>Selaginella tamariscina</i>" @default.
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- W2738948082 doi "https://doi.org/10.1098/rsos.170352" @default.
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