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- W2739027975 abstract "Abstract Mammals evolved from reptile-like ancestors, and while the mammalian heart is driven by a distinct sinus node, a sinus node is not apparent in reptiles. We characterized the myocardial systemic venous pole, the sinus venosus, in reptiles to identify the dominant pacemaker and to assess whether the sinus venosus remodels and adopts an atrium-like phenotype as observed in mammals. Anolis lizards had an extensive sinus venosus of myocardium expressing Tbx18 . A small sub-population of cells encircling the sinuatrial junction expressed Isl1 , Bmp2 , Tbx3 , and Hcn4 , homologues of genes marking the mammalian sinus node. Electrical mapping showed that hearts of Anolis lizards and Python snakes were driven from the sinuatrial junction. The electrical impulse was delayed between the sinus venosus and the right atrium, allowing the sinus venosus to contract and aid right atrial filling. In proximity of the systemic veins, the Anolis sinus venosus expressed markers of the atrial phenotype Nkx2-5 and Gja5 . In conclusion, the reptile heart is driven by a pacemaker region with an expression signature similar to that of the immature sinus node of mammals. Unlike mammals, reptiles maintain a sinuatrial delay of the impulse, allowing the partly atrialized sinus venosus to function as a chamber." @default.
- W2739027975 created "2017-07-31" @default.
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- W2739027975 date "2017-07-27" @default.
- W2739027975 modified "2023-09-25" @default.
- W2739027975 title "Morpho-functional characterization of the systemic venous pole of the reptile heart" @default.
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- W2739027975 doi "https://doi.org/10.1038/s41598-017-06291-z" @default.
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