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• W2739081532 endingPage "1458" @default.
• W2739081532 startingPage "1449" @default.
• W2739081532 abstract "Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive decline in cognitive abilities of the affected individuals. Biological markers are essential to identify individuals at early stages of the disease for timely therapeutic intervention. Currently, pathological biomarkers are detected either through cerebrospinal fluid analysis or brain imaging, or postmortem, all of which are expensive, invasive, or time consuming. Recently, some studies have shown that circulating miR-125b, miR-181c, miR-9, miR-191-5p, miR-26b-3p, and miR-28-3p may be biomarkers of AD. However, those potential biomarkers are not validated in an AD mouse model. In the current study, we found that circulating miR-125b, miR-9, and miR-191-5p are downregulated, and miR-28-3p is upregulated in an APP/PS1 transgenic mouse model of AD. Furthermore, the correlation analysis shows a positive correlation between the expression of miR-125b and cognitive function of the APP/PS1 transgenic mouse. Moreover, we also determined that the level of serum miR-125b, miR-9, and miR-191-5p were reversed in EGCG-treated APP/PS1 transgenic mouse models. Finally, the expression of miR-125b was significantly downregulated in EGCG-treated SH-SY5Y cells." @default.
• W2739081532 created "2017-07-31" @default.
• W2739081532 creator A5022335283 @default.
• W2739081532 creator A5060899844 @default.
• W2739081532 creator A5064842058 @default.
• W2739081532 date "2017-08-14" @default.
• W2739081532 modified "2023-09-30" @default.
• W2739081532 title "Identification of Circulating miR-125b as a Potential Biomarker of Alzheimer’s Disease in APP/PS1 Transgenic Mouse" @default.
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• W2739081532 doi "https://doi.org/10.3233/jad-170156" @default.
• W2739081532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28731435" @default.
• W2739081532 hasPublicationYear "2017" @default.
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