Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739103638> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2739103638 endingPage "1735" @default.
- W2739103638 startingPage "1729" @default.
- W2739103638 abstract "Background: Brain tumours are the most common solid tumours in children. More than 50% of these tumours develop in the posterior cranial fossa. Long term survivors of posterior fossa tumours (PFT) suffer from neurocognitive and memory issues. We hypothesized that serial MRI scanning of brain would show differences in hippocampal and ACC volume change in PFT patients treated with and without chemo-radiotherapy. Material and Methods: Twelve patients (8 females and 4 males) underwent 76 serial MR imaging examinations before and during treatment for posterior fossa tumours. Seven patients (4 medulloblastoma, 2 as ependymoma and 1 high grade glioma) were treated with maximum surgical resection followed by adjuvant radiotherapy and chemotherapy (Group 1). The other five patients were diagnosed as pilocytic astrocytoma who were treated only with surgery (Group 2). Hippocampal volumes were obtained manually on high-resolution 3Tesla T1-weighted images and normalised to intracranial volume, while ACC thickness and volume were obtained automatically using FreeSurfer software. Results: After the treatment period, the change in normalised hippocampal volume from baseline was significantly lower in group 1 patients compared to group 2 (mean change -0.0001470 ± 8.981e-005; Mean ± SEM vs 0.0002765 ± 9.151e-005; Mean ± SEM, respectively, P=0.004). Displayed graphically, the negative hippocampal growth trajectory in group 1 gradually returned to a positive growth pattern. There were no statistically significant changes in ACC volume and thickness. Both groups had similar rates of pre-operative hydrocephalus. Conclusion: Compared to PFT patients treated with surgery alone, PFT patients treated with chemo-radiotherapy showed lower hippocampal volumes and altered hippocampal growth trajectory. Serial quantitative MRI measures of brain may provide a neuroanatomical substrate for assessing functional impact on normal brain function following treatment of posterior fossa tumours." @default.
- W2739103638 created "2017-07-31" @default.
- W2739103638 creator A5016374565 @default.
- W2739103638 creator A5060342353 @default.
- W2739103638 date "2017-07-27" @default.
- W2739103638 modified "2023-09-23" @default.
- W2739103638 title "Serial MRI Scan of Posterior Fossa Tumours Predict Patients at Risk of Developing Neurocognitive Impairment" @default.
- W2739103638 cites W1939741655 @default.
- W2739103638 cites W1981117639 @default.
- W2739103638 cites W2009666348 @default.
- W2739103638 cites W2015218205 @default.
- W2739103638 cites W2029202229 @default.
- W2739103638 cites W2029874870 @default.
- W2739103638 cites W2031969036 @default.
- W2739103638 cites W2033200260 @default.
- W2739103638 cites W2042897626 @default.
- W2739103638 cites W2058012809 @default.
- W2739103638 cites W2063849868 @default.
- W2739103638 cites W2066462635 @default.
- W2739103638 cites W2093040093 @default.
- W2739103638 cites W2096476371 @default.
- W2739103638 cites W2099774304 @default.
- W2739103638 cites W2115094058 @default.
- W2739103638 cites W2141604895 @default.
- W2739103638 cites W2151721316 @default.
- W2739103638 cites W2162014359 @default.
- W2739103638 cites W2168093825 @default.
- W2739103638 cites W2224538742 @default.
- W2739103638 cites W43763000 @default.
- W2739103638 doi "https://doi.org/10.22034/apjcp.2017.18.7.1729" @default.
- W2739103638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5648372" @default.
- W2739103638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28748803" @default.
- W2739103638 hasPublicationYear "2017" @default.
- W2739103638 type Work @default.
- W2739103638 sameAs 2739103638 @default.
- W2739103638 citedByCount "0" @default.
- W2739103638 crossrefType "journal-article" @default.
- W2739103638 hasAuthorship W2739103638A5016374565 @default.
- W2739103638 hasAuthorship W2739103638A5060342353 @default.
- W2739103638 hasConcept C118552586 @default.
- W2739103638 hasConcept C126838900 @default.
- W2739103638 hasConcept C141071460 @default.
- W2739103638 hasConcept C142724271 @default.
- W2739103638 hasConcept C169900460 @default.
- W2739103638 hasConcept C172467417 @default.
- W2739103638 hasConcept C2777722931 @default.
- W2739103638 hasConcept C2778227246 @default.
- W2739103638 hasConcept C2778880634 @default.
- W2739103638 hasConcept C2780789225 @default.
- W2739103638 hasConcept C2781432949 @default.
- W2739103638 hasConcept C2989005 @default.
- W2739103638 hasConcept C2993788527 @default.
- W2739103638 hasConcept C502942594 @default.
- W2739103638 hasConcept C509974204 @default.
- W2739103638 hasConcept C71924100 @default.
- W2739103638 hasConceptScore W2739103638C118552586 @default.
- W2739103638 hasConceptScore W2739103638C126838900 @default.
- W2739103638 hasConceptScore W2739103638C141071460 @default.
- W2739103638 hasConceptScore W2739103638C142724271 @default.
- W2739103638 hasConceptScore W2739103638C169900460 @default.
- W2739103638 hasConceptScore W2739103638C172467417 @default.
- W2739103638 hasConceptScore W2739103638C2777722931 @default.
- W2739103638 hasConceptScore W2739103638C2778227246 @default.
- W2739103638 hasConceptScore W2739103638C2778880634 @default.
- W2739103638 hasConceptScore W2739103638C2780789225 @default.
- W2739103638 hasConceptScore W2739103638C2781432949 @default.
- W2739103638 hasConceptScore W2739103638C2989005 @default.
- W2739103638 hasConceptScore W2739103638C2993788527 @default.
- W2739103638 hasConceptScore W2739103638C502942594 @default.
- W2739103638 hasConceptScore W2739103638C509974204 @default.
- W2739103638 hasConceptScore W2739103638C71924100 @default.
- W2739103638 hasIssue "7" @default.
- W2739103638 hasLocation W27391036381 @default.
- W2739103638 hasOpenAccess W2739103638 @default.
- W2739103638 hasPrimaryLocation W27391036381 @default.
- W2739103638 hasRelatedWork W1799370427 @default.
- W2739103638 hasRelatedWork W2116917942 @default.
- W2739103638 hasRelatedWork W2384481089 @default.
- W2739103638 hasRelatedWork W2555558282 @default.
- W2739103638 hasRelatedWork W2886204545 @default.
- W2739103638 hasRelatedWork W3133177646 @default.
- W2739103638 hasRelatedWork W4206969282 @default.
- W2739103638 hasRelatedWork W4246764157 @default.
- W2739103638 hasRelatedWork W4281757768 @default.
- W2739103638 hasRelatedWork W4285803659 @default.
- W2739103638 hasVolume "18" @default.
- W2739103638 isParatext "false" @default.
- W2739103638 isRetracted "false" @default.
- W2739103638 magId "2739103638" @default.
- W2739103638 workType "article" @default.