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- W2739115819 endingPage "325" @default.
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- W2739115819 abstract "Receptors for the Fc domain of immunoglobulins [Fc receptors (FcRs)] are essential for the maintenance of antibody-mediated immune responses. FcRs consist of activating- and inhibitory-type receptors that regulate adequate thresholds for various immune cells. In particular, polymorphisms and/or gene copy-number variations of FcRs for IgG (FcγRs) are closely associated with the development of inflammatory disorders, including autoimmune diseases. Recent evidence has implicated polymorphisms of FcRs in the efficacy of monoclonal antibody (mAb)-mediated therapy. This review provides an overview of genetic variations in human FcγRs and the clinical contribution of FcγR polymorphisms in mAb treatments for cancer, autoimmune diseases and allergies." @default.
- W2739115819 created "2017-07-31" @default.
- W2739115819 creator A5072189120 @default.
- W2739115819 creator A5080686852 @default.
- W2739115819 date "2017-07-01" @default.
- W2739115819 modified "2023-10-01" @default.
- W2739115819 title "Polymorphisms of immunoglobulin receptors and the effects on clinical outcome in cancer immunotherapy and other immune diseases: a general review" @default.
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- W2739115819 doi "https://doi.org/10.1093/intimm/dxx041" @default.
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- W2739115819 hasPublicationYear "2017" @default.
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