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- W2739249774 abstract "Mild traumatic brain injury (mTBI) often results in working memory (WM) impairment, but the mechanistic relationship between the two remains elusive. We used a computational model of two cortical neuronal networks linked by myelinated callosal axons with distance-dependent conduction delays to simulate callosal dysfunction in mTBI and quantify its impact on WM. WM maintenance and termination in the model network depended on short-term synaptic plasticity. In injured networks, WM duration depended on the extent of callosal injury, consistent with clinical data. The model provides a framework for studying callosal injury-induced neurobehavioral alterations following mTBI, and, to the best of our knowledge, is the first computational model to address mTBI-induced WM impairment." @default.
- W2739249774 created "2017-07-31" @default.
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- W2739249774 date "2017-09-27" @default.
- W2739249774 modified "2023-09-23" @default.
- W2739249774 title "Callosal injury-induced working memory impairment" @default.
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- W2739249774 doi "https://doi.org/10.1097/wnr.0000000000000842" @default.
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