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- W2739310751 abstract "Introduction: Lamivudine is a cytosine nucleoside analogue clinically used for the treatment of chronic HBV infection. A major problem with long-term use of lamivudine, however, is the potential development of viral resistance to the treatment. Mutations in the YMDD motif of the hepatitis B virus DNA polymerase gene have been associated with resistance. So far, there have not been many studies reporting the genotype-dependent development of lamivudine resistance in HBV in Brazil. Objectives: The aim of the present study was to determine the possible correlation between a certain genotype and increased development of lamivudine resistance in chronic hepatitis B patients. Methods: HBV DNA was amplified by PCR from serum samples of 50 patients under lamivudine treatment, collected at the Hospital das Clinicas, FMRP, USP, and sequenced. Results: Phylogenetic analysis revealed that 29 patients (58%) were infected with genotype D, 20 (40%) with genotype A and 1 (2%) with genotype F. Mutations in the YMDD motif occurred in 20% of patients with genotype A and 27,6% of patients with genotype D. Conclusion: Despite the few number of samples, our results indicated that these variants appeared 1.38X more frequently in patients infected with genotype D than in patients infected with genotype A." @default.
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- W2739310751 date "2012-10-08" @default.
- W2739310751 modified "2023-09-23" @default.
- W2739310751 title "Hepatitis B virus genotyping in chronic hepatitis B patients with resistance to treatment with Lamivudine in Ribeirão Preto, São Paulo State." @default.
- W2739310751 hasPublicationYear "2012" @default.
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