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- W2739410889 abstract "Aim: To assess the required characteristics (cost, sensitivity and specificity) of a pharmacogenomic test for being a cost-effective prevention of angiotensin-converting enzyme inhibitors induced angioedema. Furthermore, we assessed the influence of only testing high-risk populations. Materials & methods: A decision tree was used. Results: With a willingness-to-pay threshold of €20,000 and €80,000 per quality adjusted life year, a 100% sensitive and specific test may have a maximum cost of €1.30 and €1.95, respectively. When only genotyping high-risk populations, the maximum test price would be €5.03 and €7.55, respectively. Conclusion: This theoretical pharmacogenomic test is only cost-effective at high specificity, high sensitivity and a low price. Only testing high-risk populations yields more realistic maximum test prices for cost–effectiveness of the intervention." @default.
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- W2739410889 date "2017-08-01" @default.
- W2739410889 modified "2023-09-27" @default.
- W2739410889 title "Early health technology assessments in pharmacogenomics: a case example in cardiovascular drugs" @default.
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- W2739410889 doi "https://doi.org/10.2217/pgs-2017-0063" @default.
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