FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739434905> ?p ?o ?g. }

• W2739434905 endingPage "132" @default.
• W2739434905 startingPage "122" @default.
• W2739434905 abstract "Although they are the most common neoplasms in equids, sarcoids are not fully characterized at the molecular level. Therefore, the objective of this study was to characterize the landscape of structural rearrangements, such as copy number variation (CNV) and copy neutral loss of heterozygosity (cnLOH), in the genomes of sarcoid tumor cells. This information will not only broaden our understanding of the characteristics of this genome but will also improve the general knowledge of this tumor and the mechanisms involved in its generation. To this end, Equine SNP64K Illumina microarrays were applied along with bioinformatics tools dedicated for signal intensity analysis. The analysis revealed increased instability of the genome of sarcoid cells compared with unaltered skin tissue samples, which was manifested by the prevalence of CNV and cnLOH events. Many of the identified CNVs overlapped with the other research results, but the simultaneously observed variability in the number and sizes of detected aberrations indicated a need for further studies and the development of more reliable bioinformatics algorithms. The functional analysis of genes co-localized with the identified aberrations revealed that these genes are engaged in vital cellular processes. In addition, a number of these genes directly contribute to neoplastic transformation. Furthermore, large numbers of cnLOH events identified in the sarcoids suggested that they may play no less significant roles than CNVs in the carcinogenesis of this tumor. Thus, our results indicate the importance of cnLOH and CNV in equine sarcoid oncogenesis and present a direction of future research." @default.
• W2739434905 created "2017-07-31" @default.
• W2739434905 creator A5011638155 @default.
• W2739434905 creator A5014430726 @default.
• W2739434905 creator A5031845437 @default.
• W2739434905 creator A5050810845 @default.
• W2739434905 creator A5058406062 @default.
• W2739434905 creator A5058760199 @default.
• W2739434905 creator A5069718214 @default.
• W2739434905 creator A5083253811 @default.
• W2739434905 creator A5084196958 @default.
• W2739434905 date "2017-09-01" @default.
• W2739434905 modified "2023-10-16" @default.
• W2739434905 title "Genomic landscape of copy number variation and copy neutral loss of heterozygosity events in equine sarcoids reveals increased instability of the sarcoid genome" @default.
• W2739434905 cites W1494567425 @default.
• W2739434905 cites W1690865212 @default.
• W2739434905 cites W1905465522 @default.
• W2739434905 cites W1992722091 @default.
• W2739434905 cites W1996403993 @default.
• W2739434905 cites W2004268158 @default.
• W2739434905 cites W2004864342 @default.
• W2739434905 cites W2007546146 @default.
• W2739434905 cites W2007965628 @default.
• W2739434905 cites W2012945687 @default.
• W2739434905 cites W2013469333 @default.
• W2739434905 cites W2014350856 @default.
• W2739434905 cites W2015876437 @default.
• W2739434905 cites W2021440690 @default.
• W2739434905 cites W2025050750 @default.
• W2739434905 cites W2026568437 @default.
• W2739434905 cites W2027006410 @default.
• W2739434905 cites W2027847170 @default.
• W2739434905 cites W2028915799 @default.
• W2739434905 cites W2032367243 @default.
• W2739434905 cites W2032703975 @default.
• W2739434905 cites W2038953194 @default.
• W2739434905 cites W2049512696 @default.
• W2739434905 cites W2050489856 @default.
• W2739434905 cites W2054193808 @default.
• W2739434905 cites W2054340000 @default.
• W2739434905 cites W2057015734 @default.
• W2739434905 cites W2060458028 @default.
• W2739434905 cites W2061307034 @default.
• W2739434905 cites W2065141457 @default.
• W2739434905 cites W2080719056 @default.
• W2739434905 cites W2082559623 @default.
• W2739434905 cites W2083695927 @default.
• W2739434905 cites W2083751216 @default.
• W2739434905 cites W2084709464 @default.
• W2739434905 cites W2085755265 @default.
• W2739434905 cites W2087512975 @default.
• W2739434905 cites W2089515237 @default.
• W2739434905 cites W2104097622 @default.
• W2739434905 cites W2108244474 @default.
• W2739434905 cites W2115919763 @default.
• W2739434905 cites W2122410503 @default.
• W2739434905 cites W2138632775 @default.
• W2739434905 cites W2138755755 @default.
• W2739434905 cites W2142778308 @default.
• W2739434905 cites W2143671737 @default.
• W2739434905 cites W2149681218 @default.
• W2739434905 cites W2153423767 @default.
• W2739434905 cites W2155707112 @default.
• W2739434905 cites W2159091117 @default.
• W2739434905 cites W2159881533 @default.
• W2739434905 cites W2162212014 @default.
• W2739434905 cites W2162927194 @default.
• W2739434905 cites W2165064122 @default.
• W2739434905 cites W2165562009 @default.
• W2739434905 cites W2165860917 @default.
• W2739434905 cites W2168893192 @default.
• W2739434905 cites W2288314472 @default.
• W2739434905 cites W2328400633 @default.
• W2739434905 cites W4253188015 @default.
• W2739434905 cites W4294216483 @default.
• W2739434905 doi "https://doi.org/10.1016/j.biochi.2017.07.006" @default.
• W2739434905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28743673" @default.
• W2739434905 hasPublicationYear "2017" @default.
• W2739434905 type Work @default.
• W2739434905 sameAs 2739434905 @default.
• W2739434905 citedByCount "5" @default.
• W2739434905 countsByYear W27394349052018 @default.
• W2739434905 countsByYear W27394349052020 @default.
• W2739434905 countsByYear W27394349052022 @default.
• W2739434905 countsByYear W27394349052023 @default.
• W2739434905 crossrefType "journal-article" @default.
• W2739434905 hasAuthorship W2739434905A5011638155 @default.
• W2739434905 hasAuthorship W2739434905A5014430726 @default.
• W2739434905 hasAuthorship W2739434905A5031845437 @default.
• W2739434905 hasAuthorship W2739434905A5050810845 @default.
• W2739434905 hasAuthorship W2739434905A5058406062 @default.
• W2739434905 hasAuthorship W2739434905A5058760199 @default.
• W2739434905 hasAuthorship W2739434905A5069718214 @default.
• W2739434905 hasAuthorship W2739434905A5083253811 @default.
• W2739434905 hasAuthorship W2739434905A5084196958 @default.
• W2739434905 hasConcept C104317684 @default.
• W2739434905 hasConcept C120821319 @default.
• W2739434905 hasConcept C124942203 @default.

• next