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- W2739512876 abstract "A rzzrnzber of reports izz the literature suggest that there is an inverse correlatiozz between tlze izztensity of nerve activation and the effectiveness of presynnptic receptors ttzat inhibit transmitter release. This common feature of nzazzy presynaptic inhibit0 y receptors may provide important insights into tlze mechazzism by wlzick transmitter release is controlled. Sue Duckles and D&es Budai disczrss tlze implications such a relationship between the pattern of tzerve activation and effectiveness of presytzaptic receptors has for zozderstazzdizzg ttze physiological role of neuronzodulators in general. As is often the case in scientific endeavor, observations can ahematively be viewed as annoying complications to be ignored or as unique opportunities to gain better insight into a complex physiological process, The dependence of the actions of presynaptic receptors on the intensity of stimulation has often been noted’“, and numemus investigators have exploited this phenomenon for the insights to be gained into mechanisms of COntiGl and modulation of transmitter release. The critical dependence of presynaptic receptor effect on stimulation intensity is illustrated for two distinct receptor types in Figs 1 and 2. For a given number of puises, the higher the frequency of stimulation the smaller the inhibitory effect of activating pre-ynaptic dopamine D2 receptors with the selective agonist NO437 (Ref. 4). The same phenomenon is seen with the nonselective agonist apomorphine. Furthermore, increasing the length of each train of pulses at a constant frequency also results in a decreased effect of presynaptic dopamine receptors. The effects of presynaptic opioid receptors are also dependent" @default.
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- W2739512876 date "1990-01-01" @default.
- W2739512876 modified "2023-09-24" @default.
- W2739512876 title "as critical determinant of presynaptic receptor effectiveness" @default.
- W2739512876 hasPublicationYear "1990" @default.
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