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• W2739578663 abstract "CD8+ T cells are essential for anti-tumor associated antigen (TAA) monoclonal antibody (mAb) efficacy in wild-type mice. Anti-TAA mAbs amplify the effects of T cell-based immunotherapies. Anti-TAA mAbs initiate self-vaccination against tumor antigens and inflame the tumor microenvironment. The classical view of therapeutic monoclonal antibodies (mAbs) against tumor-associated antigens (TAAs) is that their mechanism of action is dominated by signal blocking or the cytotoxicity of Fc-driven innate immune effector functions. We review here a mounting body of evidence that anti-TAA mAbs are capable of profoundly synergizing with T cell-directed immunotherapies such as checkpoint blockade and adoptive cell therapy. Two key components account for this synergy: (i) a self-vaccinal effect mediated by dendritic cells (DCs); and (ii) an inflammatory repolarization of the tumor microenvironment. Efficient exploitation of these mechanisms has tremendous therapeutic potential. The classical view of therapeutic monoclonal antibodies (mAbs) against tumor-associated antigens (TAAs) is that their mechanism of action is dominated by signal blocking or the cytotoxicity of Fc-driven innate immune effector functions. We review here a mounting body of evidence that anti-TAA mAbs are capable of profoundly synergizing with T cell-directed immunotherapies such as checkpoint blockade and adoptive cell therapy. Two key components account for this synergy: (i) a self-vaccinal effect mediated by dendritic cells (DCs); and (ii) an inflammatory repolarization of the tumor microenvironment. Efficient exploitation of these mechanisms has tremendous therapeutic potential." @default.
• W2739578663 created "2017-08-08" @default.
• W2739578663 creator A5048283562 @default.
• W2739578663 date "2017-09-01" @default.
• W2739578663 modified "2023-10-17" @default.
• W2739578663 title "Antitumor Antibodies Can Drive Therapeutic T Cell Responses" @default.
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• W2739578663 doi "https://doi.org/10.1016/j.trecan.2017.07.001" @default.
• W2739578663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5657573" @default.
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