Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739584564> ?p ?o ?g. }
- W2739584564 endingPage "1412" @default.
- W2739584564 startingPage "1402" @default.
- W2739584564 abstract "The expression of PD-L1 in breast cancer is associated with estrogen receptor negativity, chemoresistance and epithelial-to-mesenchymal transition (EMT), all of which are common features of a highly tumorigenic subpopulation of cancer cells termed cancer stem cells (CSCs). Hitherto, the expression and intrinsic role of PD-L1 in the dynamics of breast CSCs has not been investigated. To address this issue, we used transcriptomic datasets, proteomics and several in vitro and in vivo assays. Expression profiling of a large breast cancer dataset (530 patients) showed statistically significant correlation (p < 0.0001, r = 0.36) between PD-L1 expression and stemness score of breast cancer. Specific knockdown of PD-L1 using ShRNA revealed its critical role in the expression of the embryonic stem cell transcriptional factors: OCT-4A, Nanog and the stemness factor, BMI1. Conversely, these factors could be induced upon PD-L1 ectopic expression in cells that are normally PD-L1 negative. Global proteomic analysis hinted for the central role of AKT in the biology of PD-L1 expressing cells. Indeed, PD-L1 positive effect on OCT-4A and Nanog was dependent on AKT activation. Most importantly, downregulation of PD-L1 compromised the self-renewal capability of breast CSCs in vitro and in vivo as shown by tumorsphere formation assay and extreme limiting dilution assay, respectively. This study demonstrates a novel role for PD-L1 in sustaining stemness of breast cancer cells and identifies the subpopulation and its associated molecular pathways that would be targeted upon anti-PD-L1 therapy." @default.
- W2739584564 created "2017-08-08" @default.
- W2739584564 creator A5003688042 @default.
- W2739584564 creator A5018442918 @default.
- W2739584564 creator A5019535388 @default.
- W2739584564 creator A5025251801 @default.
- W2739584564 creator A5044788921 @default.
- W2739584564 creator A5048515244 @default.
- W2739584564 creator A5060229867 @default.
- W2739584564 creator A5079182899 @default.
- W2739584564 creator A5085492328 @default.
- W2739584564 date "2017-06-30" @default.
- W2739584564 modified "2023-10-17" @default.
- W2739584564 title "PD‐L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation" @default.
- W2739584564 cites W1805581579 @default.
- W2739584564 cites W1972602074 @default.
- W2739584564 cites W1994238092 @default.
- W2739584564 cites W1999435920 @default.
- W2739584564 cites W2000609012 @default.
- W2739584564 cites W2000749710 @default.
- W2739584564 cites W2009725995 @default.
- W2739584564 cites W2016514257 @default.
- W2739584564 cites W2028240776 @default.
- W2739584564 cites W2037150053 @default.
- W2739584564 cites W2039147606 @default.
- W2739584564 cites W2044702943 @default.
- W2739584564 cites W2049462796 @default.
- W2739584564 cites W2050054104 @default.
- W2739584564 cites W2057473045 @default.
- W2739584564 cites W2063401578 @default.
- W2739584564 cites W2068943550 @default.
- W2739584564 cites W2096283457 @default.
- W2739584564 cites W2099175643 @default.
- W2739584564 cites W2101650407 @default.
- W2739584564 cites W2104666893 @default.
- W2739584564 cites W2127063807 @default.
- W2739584564 cites W2128338098 @default.
- W2739584564 cites W2131176934 @default.
- W2739584564 cites W2135925682 @default.
- W2739584564 cites W2152897456 @default.
- W2739584564 cites W2166779240 @default.
- W2739584564 cites W2168491140 @default.
- W2739584564 cites W2460040603 @default.
- W2739584564 cites W2462538267 @default.
- W2739584564 cites W2560367415 @default.
- W2739584564 cites W2607097093 @default.
- W2739584564 doi "https://doi.org/10.1002/ijc.30834" @default.
- W2739584564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5575465" @default.
- W2739584564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28614911" @default.
- W2739584564 hasPublicationYear "2017" @default.
- W2739584564 type Work @default.
- W2739584564 sameAs 2739584564 @default.
- W2739584564 citedByCount "156" @default.
- W2739584564 countsByYear W27395845642018 @default.
- W2739584564 countsByYear W27395845642019 @default.
- W2739584564 countsByYear W27395845642020 @default.
- W2739584564 countsByYear W27395845642021 @default.
- W2739584564 countsByYear W27395845642022 @default.
- W2739584564 countsByYear W27395845642023 @default.
- W2739584564 crossrefType "journal-article" @default.
- W2739584564 hasAuthorship W2739584564A5003688042 @default.
- W2739584564 hasAuthorship W2739584564A5018442918 @default.
- W2739584564 hasAuthorship W2739584564A5019535388 @default.
- W2739584564 hasAuthorship W2739584564A5025251801 @default.
- W2739584564 hasAuthorship W2739584564A5044788921 @default.
- W2739584564 hasAuthorship W2739584564A5048515244 @default.
- W2739584564 hasAuthorship W2739584564A5060229867 @default.
- W2739584564 hasAuthorship W2739584564A5079182899 @default.
- W2739584564 hasAuthorship W2739584564A5085492328 @default.
- W2739584564 hasBestOaLocation W27395845641 @default.
- W2739584564 hasConcept C104317684 @default.
- W2739584564 hasConcept C107459253 @default.
- W2739584564 hasConcept C121608353 @default.
- W2739584564 hasConcept C145103041 @default.
- W2739584564 hasConcept C173396325 @default.
- W2739584564 hasConcept C202751555 @default.
- W2739584564 hasConcept C207701140 @default.
- W2739584564 hasConcept C2777933648 @default.
- W2739584564 hasConcept C2780932548 @default.
- W2739584564 hasConcept C28328180 @default.
- W2739584564 hasConcept C502942594 @default.
- W2739584564 hasConcept C530470458 @default.
- W2739584564 hasConcept C54355233 @default.
- W2739584564 hasConcept C55427017 @default.
- W2739584564 hasConcept C62478195 @default.
- W2739584564 hasConcept C75217442 @default.
- W2739584564 hasConcept C81885089 @default.
- W2739584564 hasConcept C86554907 @default.
- W2739584564 hasConcept C86803240 @default.
- W2739584564 hasConcept C95444343 @default.
- W2739584564 hasConcept C97037327 @default.
- W2739584564 hasConceptScore W2739584564C104317684 @default.
- W2739584564 hasConceptScore W2739584564C107459253 @default.
- W2739584564 hasConceptScore W2739584564C121608353 @default.
- W2739584564 hasConceptScore W2739584564C145103041 @default.
- W2739584564 hasConceptScore W2739584564C173396325 @default.
- W2739584564 hasConceptScore W2739584564C202751555 @default.
- W2739584564 hasConceptScore W2739584564C207701140 @default.