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- W2739683602 abstract "Introduction: Organotin(IV) dithiocarbamate is one of metal-based compounds that are actively explored by researchers due to the diversity of their molecular structures which affects their biological activities. A number of studies have found that organotin(IV) dithiocarbamate compounds have the potential to be developed as anti-cancer agents because they can induce very strong cytotoxic effects even when used at low concentrations. Method: Two new diorganotin(IV) dithiocarbamate compounds, which are dimethyltin(IV) bis(2-methoxyethyl) dithiocarbamate ( C1 ) and diphenyltin(IV) bis(2-methoxyethyl) dithiocarbamate ( C2 ) were tested for toxicity against human erythroleukemia cells (K562). The potential of both compounds to induce cytotoxicity against K562 cells was determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a treatment duration of 24 hours. The mode of K562 cells’ death induced by both compounds was determined by Annexin V-FITC/PI staining assays for treatment duration of 24 hours using the IC 50 values for each compound. Results: This study found that both compounds were able to induce anti-proliferative effect against K562 cells. However, C2 showed stronger cytotoxicity against K562 cells with an IC 50 value of 5.0 µM compared to C1 which has an IC 50 value of 22.0 µM. Interestingly, both of these compounds were found to induce K562 cells’ death via apoptosis. Conclusion: Both compounds showed good potential to be developed into anti-leukemic agents due to their strong cytotoxicity against K562 cells leading to induction of cell death by apoptosis. Further studies regarding the mechanisms of action of these compounds should be conducted to explore their potential to be developed into anti-leukemic agents." @default.
- W2739683602 created "2017-08-08" @default.
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- W2739683602 date "2017-06-20" @default.
- W2739683602 modified "2023-09-27" @default.
- W2739683602 title "Cytotoxicity Assessment and the Mode of Cell Death Induced by Diorganotin(IV) bis(2-methoxyethyl) dithiocarbamate Compounds in Human Erythroleukemia Cells (K562)" @default.
- W2739683602 hasPublicationYear "2017" @default.
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