Matches in SemOpenAlex for { <https://semopenalex.org/work/W2739685033> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2739685033 abstract "Interleukin (IL)2 signaling requires the dimerization oftheIL-2receptor f3(IL-2Rf3) andcommony ('yc) chains. Theycisalsoacomponent ofthereceptors for IL-4, IL-7, andIL-9. Toassess theextent androleofthe receptor signal transducing system utilizing theycchain on humanintestinal epithelial cells, theexpression ofyc,IL-2Rj3, andreceptor chains specific forIL-4, IL-7, andIL-9was assessed byreverse transcription-coupled PCRonhuman intestinal epithelial cell lines andonisolated primary human intestinal epithelial cells. Caco-2, HT-29, andT-84cells were foundtoexpress transcripts fortheycandIL-4Rchains constitutively. IL-2Rj8 chain expression wasdemonstrated in Caco-2 andHT-29butnotinT-84cells. Noneofthecell lines expressed mRNAfortheIL-2Rachain. After stimulation with epidermal growth factor for24hCaco-2, HT-29, andT-84cells expressed transcripts forIL-7R. Inaddition, Caco-2and HT-29cells expressed mRNA fortheIL-9R. Receptors for IL-2, IL-4, IL-7, andIL-9onintestinal epithelial cells lines appeared tobefunctional; stimulation withthese cytokines caused rapid tyrosine phosphorylation ofproteins. Therele- vance oftheobservations inintestinal epithelial cell lines for intestinal epithelial function invivowassupported bythe demonstration oftranscripts foryc,IL-2Rg3, IL-4R, IL-7R, andIL-9Rinprimary humanintestinal epithelial cells. Interleukin (IL) 2appears toplay apivotal role inregulating immunecell populations, exerting its effects through binding tospecific cell surface receptors. TheIL-2receptor (IL-2R) consists ofthree membrane proteins: theIL-2Rachain, the IL-2R13 chain, andthecommony(yc) chain (1). Different combinations ofthese receptors onhumancells give rise to high-, intermediate-, andlow-affinity binding sites forIL-2(1). TheIL-2Rf3 andycchains arerequired forligand internal- ization andsignal transduction (2). Theycchain hasbeen showntodimerize also withtheIL-4R(3), IL-7R(4), and IL-9R(5)chains toformsignal transducing receptors forthese cytokines. Thecytokines utilizing theycchain intheir receptor com- plexes havebeenidentified (1-5) through their regulatory effects onT andB lymphocytes. Little isknownabout the function ofthese cytokine receptors andtheir intracellular signaling pathways innonhematopoetic cells. Inthis report we demonstrate that intestinal epithelial cells areable toutilize theycreceptor signal transducing system. Bothhumanintes- tinal epithelial cell lines andprimary humanintestinal epithe- lial cells areable toexpress transcripts forzc, IL-2R,B, IL-4R, IL-7R, andIL-9Rchains. Thesereceptors arefunctional, as demonstrated bytheinitiation oftyrosine phosphorylation of proteins within intestinal epithelial cells byIL-2, IL-4, IL-7, andIL-9. Intestinal epithelial cells maybeintegrated into the" @default.
- W2739685033 created "2017-08-08" @default.
- W2739685033 creator A5072363152 @default.
- W2739685033 date "1995-01-01" @default.
- W2739685033 modified "2023-09-24" @default.
- W2739685033 title "Humanintestinal epithelial cells expressfunctional cytokine receptors sharing thecommonycchainoftheinterleukin 2receptor" @default.
- W2739685033 cites W2063814906 @default.
- W2739685033 hasPublicationYear "1995" @default.
- W2739685033 type Work @default.
- W2739685033 sameAs 2739685033 @default.
- W2739685033 citedByCount "0" @default.
- W2739685033 crossrefType "journal-article" @default.
- W2739685033 hasAuthorship W2739685033A5072363152 @default.
- W2739685033 hasConcept C153911025 @default.
- W2739685033 hasConcept C170493617 @default.
- W2739685033 hasConcept C197462201 @default.
- W2739685033 hasConcept C203014093 @default.
- W2739685033 hasConcept C2778690821 @default.
- W2739685033 hasConcept C54355233 @default.
- W2739685033 hasConcept C55493867 @default.
- W2739685033 hasConcept C62478195 @default.
- W2739685033 hasConcept C81885089 @default.
- W2739685033 hasConcept C86803240 @default.
- W2739685033 hasConcept C95444343 @default.
- W2739685033 hasConceptScore W2739685033C153911025 @default.
- W2739685033 hasConceptScore W2739685033C170493617 @default.
- W2739685033 hasConceptScore W2739685033C197462201 @default.
- W2739685033 hasConceptScore W2739685033C203014093 @default.
- W2739685033 hasConceptScore W2739685033C2778690821 @default.
- W2739685033 hasConceptScore W2739685033C54355233 @default.
- W2739685033 hasConceptScore W2739685033C55493867 @default.
- W2739685033 hasConceptScore W2739685033C62478195 @default.
- W2739685033 hasConceptScore W2739685033C81885089 @default.
- W2739685033 hasConceptScore W2739685033C86803240 @default.
- W2739685033 hasConceptScore W2739685033C95444343 @default.
- W2739685033 hasLocation W27396850331 @default.
- W2739685033 hasOpenAccess W2739685033 @default.
- W2739685033 hasPrimaryLocation W27396850331 @default.
- W2739685033 hasRelatedWork W1489754199 @default.
- W2739685033 hasRelatedWork W1924893448 @default.
- W2739685033 hasRelatedWork W1985517322 @default.
- W2739685033 hasRelatedWork W2001815696 @default.
- W2739685033 hasRelatedWork W2022606300 @default.
- W2739685033 hasRelatedWork W2028583067 @default.
- W2739685033 hasRelatedWork W2057505571 @default.
- W2739685033 hasRelatedWork W2077786734 @default.
- W2739685033 hasRelatedWork W2080290413 @default.
- W2739685033 hasRelatedWork W2095253629 @default.
- W2739685033 hasRelatedWork W2098965772 @default.
- W2739685033 hasRelatedWork W2107230539 @default.
- W2739685033 hasRelatedWork W2130285707 @default.
- W2739685033 hasRelatedWork W2135491202 @default.
- W2739685033 hasRelatedWork W2143655571 @default.
- W2739685033 hasRelatedWork W2149639909 @default.
- W2739685033 hasRelatedWork W2155470553 @default.
- W2739685033 hasRelatedWork W2171404313 @default.
- W2739685033 hasRelatedWork W2187625666 @default.
- W2739685033 hasRelatedWork W3106218763 @default.
- W2739685033 isParatext "false" @default.
- W2739685033 isRetracted "false" @default.
- W2739685033 magId "2739685033" @default.
- W2739685033 workType "article" @default.