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- W2739703670 abstract "The natural process of silk spinning covers a fascinating versatility of aggregate states, ranging from colloidal solutions through hydrogels to solid systems. The transition among these states is controlled by a carefully orchestrated process in vivo. Major players within the natural process include the control of spatial pH throughout passage of the silk dope, the composition and type of ions, and fluid flow mechanics within the duct, respectively. The function of these input parameters on the spinning process is reviewed before detailing their impact on the design and manufacture of silk based drug delivery systems (DDS). Examples are reported including the control of hydrogel formation during storage or significant parameters controlling precipitation in the presence of appropriate salts, respectively. The review details the use of silk fibroin (SF) to develop liquid, semiliquid or solid DDS with a focus on the control of SF crystallization, particle formation, and drug–SF interaction for tailored drug load." @default.
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- W2739703670 date "2017-08-01" @default.
- W2739703670 modified "2023-09-23" @default.
- W2739703670 title "Injectable and release-controlled hydrogel based on xanthan gum and silk fibroin" @default.
- W2739703670 doi "https://doi.org/10.1016/j.jconrel.2017.03.351" @default.
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